BOC-L-Proline
- CAS No.15761-39-4
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity BOC-L-Proline for peptide synthesis and API manufacturing. CAS 15761-39-4. ≥99% purity with full COA support.
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Product Overview
BOC-L-Proline is a premier protected amino acid derivative extensively utilized in modern pharmaceutical synthesis and peptide chemistry. As a critical building block, it features a tert-butoxycarbonyl (Boc) protecting group on the nitrogen atom of the L-proline structure. This specific protection strategy is essential for preventing unwanted side reactions during complex multi-step organic syntheses, ensuring high yield and stereochemical integrity in the final product.
Our manufacturing facility produces this compound under strict quality control protocols, adhering to international standards for pharmaceutical intermediates. The material is characterized by its exceptional stability, solubility in common organic solvents, and high optical purity, making it an ideal choice for demanding synthetic applications.
Key Specifications
We maintain rigorous testing standards to ensure every batch meets the required specifications for industrial and research use. The following table outlines the typical physical and chemical properties of our BOC-L-Proline:
| Parameter | Specification | Typical Result |
|---|---|---|
| Appearance | White to off-white powder | White powder |
| CAS Number | 15761-39-4 | 15761-39-4 |
| Molecular Formula | C10H17NO4 | C10H17NO4 |
| Assay (HPLC) | ≥99.0% | 99.45% |
| Specific Rotation | -58.00° to -63.00° | -59.21° |
| Water Content (K.F.) | ≤0.50% | 0.01% |
| Residue on Ignition | ≤0.50% | 0.24% |
| Chiral Purity (Boc-D-Pro) | ≤0.05% | 0.04% |
| Total Impurities | ≤1.00% | 0.55% |
Industrial Applications
This protected amino acid serves as a vital intermediate in the production of various active pharmaceutical ingredients (APIs). Notably, it is used in the synthesis of antiviral agents such as Daclatasvir, which targets the HCV protein NS5A for the treatment of Hepatitis C. Beyond antiviral drugs, BOC-L-Proline is a fundamental component in the solid-phase and solution-phase synthesis of peptides and peptidomimetics.
- Pharmaceutical API Synthesis: Essential for constructing complex drug molecules.
- Peptide Chemistry: Used as a building block for custom peptide sequences.
- Research and Development: Suitable for laboratory-scale organic synthesis projects.
- Contract Manufacturing: Available for large-scale production requirements.
Quality Assurance and Packaging
Quality is our top priority. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) detailing all test results against our factory standards. We employ advanced HPLC techniques to verify purity and chiral integrity, ensuring minimal presence of enantiomeric impurities like Boc-D-proline.
The product is packaged in 25kg drums to ensure stability during transit. For optimal preservation, we recommend storing the material in a closed container within a cool, dry place, ideally below 0°C. This prevents moisture absorption and maintains the chemical stability of the Boc protecting group over extended periods. Our global logistics network ensures timely delivery to manufacturers and research institutions worldwide.
