Intermediates

Chlorodipiperidinocarbenium Hexafluorophosphate

  • CAS No.161308-40-3
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity Chlorodipiperidinocarbenium Hexafluorophosphate (CAS 161308-40-3) is a premium condensation reagent designed for efficient peptide synthesis and organic coupling reactions.

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Product Technical Details

Product Overview

Chlorodipiperidinocarbenium Hexafluorophosphate, commonly known as PipClU, is a highly specialized uronium-type coupling reagent utilized extensively in modern organic synthesis and peptide chemistry. As a critical intermediate, this compound facilitates efficient condensation reactions, enabling the formation of amide bonds with minimal racemization. Our manufacturing process ensures exceptional purity levels, making it an ideal choice for both laboratory research and large-scale pharmaceutical production.

This reagent is particularly valued for its stability and reactivity profile, which surpasses many traditional coupling agents. The hexafluorophosphate counterion contributes to its solubility characteristics and overall performance in various solvent systems. We adhere to strict quality control protocols to guarantee consistency across every batch, supporting reliable experimental outcomes and industrial processes.

Technical Specifications

Parameter Value
Chemical Name Chlorodipiperidinocarbenium Hexafluorophosphate
CAS Number 161308-40-3
Molecular Formula C11H20ClF6N2P
Molecular Weight 360.71 g/mol
Appearance White crystal powder
Purity (HPLC) ≥99.0%
Melting Point 120-122°C

Industrial Applications

The primary application of Chlorodipiperidinocarbenium Hexafluorophosphate lies in peptide synthesis, where it acts as a potent condensation agent. It is frequently employed in solid-phase peptide synthesis (SPPS) and solution-phase reactions to activate carboxylic acids for nucleophilic attack by amines. Beyond peptide chemistry, this reagent is applicable in the synthesis of complex organic molecules requiring precise amide bond formation.

Researchers and process chemists utilize this compound for its ability to minimize side reactions and improve overall yield. Its compatibility with various protecting groups makes it a versatile tool in multi-step synthesis routes. Whether for developing new pharmaceutical APIs or producing fine chemicals, this reagent provides the reliability needed for critical synthetic transformations.

Quality Assurance and Storage

We maintain rigorous quality standards, providing a Certificate of Analysis (COA) with every shipment to verify purity and identity. The product is packaged in secure, moisture-resistant containers, typically 25 kg drums, though custom packaging solutions are available to meet specific client requirements. Proper storage is essential to maintain stability; we recommend keeping the material in a cool, ventilated area away from direct sunlight and moisture sources.

Our global supply chain ensures timely delivery to laboratories and manufacturing facilities worldwide. As a dedicated manufacturer, we offer technical support to assist with integration into your specific synthesis protocols. Choose our high-performance Chlorodipiperidinocarbenium Hexafluorophosphate for consistent results and superior chemical efficiency in your production workflows.