Intermediates

Cyclopentyl Methyl Ether

  • CAS No.5614-37-9
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity Cyclopentyl Methyl Ether (CPME) CAS 5614-37-9. A green, hydrophobic solvent alternative to THF and dioxane for pharmaceutical synthesis.

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Product Technical Details

Product Overview

Cyclopentyl Methyl Ether (CPME), systematically known as Methoxycyclopentane, represents a significant advancement in modern green chemistry solvents. Identified by CAS number 5614-37-9, this hydrophobic ether has emerged as a superior, safer alternative to traditional ethereal solvents such as tetrahydrofuran (THF), 1,4-dioxane, and methyl tert-butyl ether (MTBE). Our manufacturing process ensures exceptional purity levels, making it ideally suited for demanding pharmaceutical intermediates and fine chemical synthesis applications where consistency is paramount.

As a next-generation solvent, CPME offers an outstanding balance of stability, safety, and performance. It is characterized by low toxicity, high hydrophobicity, and remarkable resistance to peroxide formation, which significantly enhances safety during long-term storage and handling. The global chemical industry increasingly adopts CPME to meet stringent Environmental, Health, and Safety (EHS) regulations prevalent in Europe and the United States, facilitating a gradual replacement of legacy solvent systems in production facilities.

Technical Specifications

Our Cyclopentyl Methyl Ether is produced under rigorous quality control standards to guarantee consistency across all batches. The following table outlines the key physical and chemical properties verified through our analytical laboratories:

ParameterSpecification
AppearanceColorless Clear Liquid
CAS Number5614-37-9
Molecular FormulaC6H12O
Molecular Weight100.16 g/mol
Purity (GC)≥ 99.0%
Water Content≤ 300 ppm
Boiling Point106 °C
Density0.86 g/cm³
Flash Point6.5 °C

Key Advantages

  • High Hydrophobicity: Facilitates easy separation from aqueous layers, reducing waste liquid volume and simplifying solvent recovery processes.
  • Low Peroxide Formation: Enhanced safety profile compared to other ethers, minimizing explosion risks during storage, distillation, and concentration.
  • Azeotropic Dehydration: Capable of forming an azeotrope with water, allowing for efficient drying processes using molecular sieves or distillation.
  • Wide Liquid Range: Stable from very low temperatures (-140 °C) to elevated temperatures, enabling versatile reaction conditions from cryogenic to reflux.
  • Chemical Stability: Resistant to strong acids and bases, ensuring compatibility with various catalytic systems and sensitive intermediates.
  • Energy Efficiency: Low latent heat of evaporation allows for energy-efficient distillation recovery, aligning with sustainable manufacturing goals.

Industrial Applications

CPME is widely utilized as a primary reaction solvent in complex organic synthesis. It supports a variety of critical transformations including Grignard reactions, Suzuki coupling, Buchwald amination, and metal reduction processes using agents like sodium borohydride or lithium aluminum hydride. Additionally, it serves as an effective extraction and recrystallization solvent in pharmaceutical manufacturing, improving yield and product quality. Its utility extends beyond synthesis into the coatings industry as a resin solvent and in the electronics sector for precision cleaning processes. By replacing halogenated hydrocarbons and conventional esters, CPME helps manufacturers reduce their environmental footprint while maintaining high reaction rates.

Quality Assurance

We are committed to delivering premium quality chemicals to our global partners. Each batch of Cyclopentyl Methyl Ether undergoes rigorous testing via Gas Chromatography (GC) and Karl Fischer titration to confirm identity, purity, and water content. Certificates of Analysis (COA) are provided with every shipment to ensure full compliance with international standards. Our robust supply chain ensures reliable delivery for bulk orders, supporting your production schedules without interruption.