D-Alanine
- CAS No.338-69-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity D-Alanine (CAS 338-69-2), a key chiral building block for pharmaceutical intermediates and specialty chemical synthesis.
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Product Overview
D-Alanine is the D-enantiomer of the non-essential amino acid alanine, serving as a critical chiral synthon in the development of enantiomerically pure active pharmaceutical ingredients (APIs). With a molecular formula of C3H7NO2 and a molecular weight of 89.09 g/mol, this compound exhibits high optical purity and stringent quality control, making it indispensable in asymmetric synthesis and advanced organic chemistry applications.
Specifications
| Molecular Formula | C3H7NO2 |
|---|---|
| Molecular Weight | 89.093 g/mol |
| Melting Point | 278–282°C |
| Specific Rotation [α]D²⁰ | -14.3° to -15.3° |
| Assay | 98.0%–101.0% |
| Appearance | White crystals or crystalline powder |
| Loss on Drying | ≤0.20% |
| Residue on Ignition | ≤0.20% |
| Heavy Metals (as Pb) | ≤10 ppm |
| Arsenic (As₂O₃) | ≤2 ppm |
Industrial Applications
D-Alanine functions primarily as a high-value intermediate in the pharmaceutical and fine chemical industries. Its core applications include:
- Serving as a chiral precursor in the synthesis of antibiotics, particularly those targeting bacterial cell wall biosynthesis.
- Acting as a building block for the production of pantothenic acid (vitamin B5) and its calcium salt, calcium pantothenate.
- Contributing to the manufacture of bioactive peptides, carnosine analogs, and bone-targeting agents such as pamidronate derivatives.
- Enabling the development of novel sweeteners and other functional molecules requiring defined stereochemistry.
Due to its role as a human and microbial metabolite, D-Alanine also finds use in biochemical research and diagnostic reagent formulations. As a non-racemic, enantiopure compound, it supports green and efficient synthetic routes that align with modern regulatory expectations for stereochemical integrity in drug substances.
Handling and Storage
Store in a cool, dry, and well-ventilated area. Keep container tightly closed to prevent moisture absorption. Standard industrial hygiene practices should be followed during handling. Supplied in 25 kg fiber drums, with custom packaging available upon request.
