Intermediates

Dibenzo-18-crown-6

  • CAS No.14187-32-7
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity Dibenzo-18-crown-6 (CAS 14187-32-7), a versatile macrocyclic polyether widely used as a phase transfer catalyst and ion-selective reagent in pharmaceutical and fine chemical synthesis.

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Product Technical Details

Product Overview

Dibenzo-18-crown-6 is a highly selective macrocyclic polyether compound renowned for its exceptional ability to complex with alkali metal cations, particularly potassium ions. With the molecular formula C20H24O6 and a molecular weight of 360.40 g/mol, this crown ether serves as a critical enabler in numerous synthetic transformations within the pharmaceutical, analytical, and materials science sectors. Its rigid dibenzo-fused structure enhances thermal stability and binding specificity compared to non-aromatic analogs.

Specifications

Molecular FormulaC20H24O6
Molecular Weight360.40 g/mol
CAS Number14187-32-7
AppearanceWhite to almost white crystalline powder
Purity≥97.0%
Moisture<1.0%
Heavy Metals<0.0005%
Melting Point162–164 °C (lit.)
Boiling Point380–384 °C at 679 mmHg
Density1.108 g/cm³
Refractive Index1.500

Industrial Applications

As a specialized intermediate, Dibenzo-18-crown-6 plays a pivotal role in advanced organic synthesis and process chemistry. Key applications include:

  • Serving as an efficient phase transfer catalyst (PTC) to facilitate reactions between immiscible phases, significantly improving yields and reaction kinetics in nucleophilic substitutions and oxidations.
  • Enabling selective ion recognition and transport in analytical chemistry for the enrichment, separation, and masking of specific metal ions—especially potassium—in complex matrices.
  • Functioning as a building block in the development of ion-conductive polymers and liquid crystal display (LCD) components for electronic materials research.
  • Supporting biochemical studies involving ion channel mimetics and membrane transport models due to its well-defined host-guest chemistry.

Stored in a tightly sealed container under cool, dry, and well-ventilated conditions, this compound maintains stability and performance throughout its shelf life. Supplied in standard 25 kg drums or customized packaging upon request, it meets stringent quality requirements for global B2B supply chains.