Diethoxyphosphorylmethyl 4-Methylbenzenesulfonate
- CAS No.31618-90-3
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity Diethoxyphosphorylmethyl 4-Methylbenzenesulfonate serves as a critical phosphonate intermediate for antiviral drug synthesis, ensuring optimal reaction efficiency.
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Product Overview
Diethoxyphosphorylmethyl 4-Methylbenzenesulfonate, frequently recognized in industrial contexts as Diethyl (tosyloxy)methylphosphonate, represents a specialized organophosphorus compound essential for modern pharmaceutical manufacturing. This sophisticated chemical intermediate features a phosphonate ester structure linked to a tosylate leaving group, making it highly reactive and suitable for nucleophilic substitution reactions. Our facility produces this compound under strict quality control protocols to ensure consistency across large-scale batches.
As a key building block in medicinal chemistry, this substance plays a pivotal role in the construction of nucleotide analogs. The presence of the diethoxyphosphoryl group provides the necessary phosphorus backbone required for antiviral activity, while the tosylate moiety facilitates efficient coupling during synthetic sequences. We prioritize industrial purity standards to minimize downstream purification burdens for our clients.
Technical Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 31618-90-3 |
| Molecular Formula | C12H19O6PS |
| Molecular Weight | 322.31 g/mol |
| Appearance | Clear colorless to slight yellow liquid |
| Purity | ≥98.5% |
| Moisture Content | ≤0.5% |
| Density | 1.255 g/cm3 |
| Boiling Point | 441.7°C |
| Flash Point | 92°C |
| Refractive Index | 1.498 |
Industrial Applications
The primary application of this chemical lies within the pharmaceutical sector, specifically serving as a vital intermediate in the synthesis of Tenofovir. Tenofovir is a well-known nucleotide reverse transcriptase inhibitor used in the treatment of HIV and chronic hepatitis B. The high purity of our Diethoxyphosphorylmethyl 4-Methylbenzenesulfonate ensures that the subsequent coupling reactions proceed with high yield and minimal impurity formation.
Beyond antiviral therapeutics, this phosphonate derivative is valuable for research and development in organic synthesis. Chemists utilize its reactive tosylate group to introduce phosphonate functionalities into complex molecular architectures. Our manufacturing process is designed to support both pilot-scale research and commercial production needs, providing flexibility for various project requirements.
Quality Assurance and Safety
We maintain a robust quality management system to guarantee product integrity. Every batch undergoes rigorous testing using advanced analytical techniques such as HPLC and NMR to verify identity and purity levels. A Certificate of Analysis (COA) is provided with each shipment, detailing all critical quality attributes. Impurities such as Toluene and Ethyl P-Toluenesulfonate are strictly controlled to remain below specified limits.
Regarding safety, this material should be handled in accordance with standard chemical safety practices. Due to its flash point of 92°C, it should be stored away from open flames and high heat sources. We recommend storage in a cool, ventilated area to maintain stability over time. Our packaging options include 25 kg drums, with custom packaging available upon request to suit specific logistics needs.
Why Choose Our Manufacturer
As a dedicated chemical manufacturer, we offer competitive bulk pricing without compromising on quality. Our global supply chain ensures timely delivery to international markets. We provide comprehensive technical support to assist with integration into your specific synthesis routes. Partner with us for reliable supply, documented quality, and a commitment to regulatory compliance in pharmaceutical intermediate manufacturing.
