Intermediates

Diethyl 2-Propylpropanedioate

  • CAS No.2163-48-6
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity Diethyl 2-Propylpropanedioate (CAS 2163-48-6), a versatile intermediate for organic and pharmaceutical synthesis.

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Product Technical Details

Product Overview

Diethyl 2-Propylpropanedioate (CAS 2163-48-6) is a high-purity malonate ester widely employed as a key building block in advanced organic synthesis. With a molecular formula of C10H18O4 and a molecular weight of 202.25 g/mol, this compound serves as a critical intermediate in the development of complex pharmaceutical active ingredients and fine chemical derivatives. Its structural versatility enables facile alkylation, condensation, and cyclization reactions, making it indispensable in multi-step synthetic pathways.

Specifications

Molecular FormulaC10H18O4
Molecular Weight202.25 g/mol
Density0.987 g/mL at 25 °C
Boiling Point221–222 °C
Flash Point197 °F
Refractive Indexn20/D 1.418
AppearanceWhite powder
Purity≥98.0%
Moisture Content0.25%
Impurity0.3%

Industrial Applications

This malonate derivative is primarily utilized as a specialty intermediate in the pharmaceutical and agrochemical industries. Its reactivity profile supports the construction of carbon-carbon bonds, enabling the synthesis of substituted carboxylic acids, heterocycles, and other pharmacophores. Common applications include:

  • Serving as a precursor in the preparation of barbiturates and other cyclic compounds
  • Facilitating Knoevenagel condensations for unsaturated acid derivatives
  • Acting as a substrate in Michael addition reactions for complex molecule assembly

Stored in a tightly sealed container under cool, dry, and well-ventilated conditions, Diethyl 2-Propylpropanedioate maintains stability and performance during extended shelf life. Standard packaging is 25 kg per drum, with custom options available to meet specific industrial requirements.