Diethyl(3-pyridyl)borane
- CAS No.89878-14-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity Diethyl(3-pyridyl)borane (CAS 89878-14-8), a key boron-containing intermediate for advanced pharmaceutical synthesis.
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Product Overview
Diethyl(3-pyridyl)borane is a high-value organoboron compound widely employed as a specialized building block in modern medicinal chemistry and fine chemical manufacturing. With its well-defined pyridyl-borane architecture, this reagent facilitates critical carbon-carbon bond-forming transformations, particularly in Suzuki-Miyaura cross-coupling reactions. Its structural precision and reactivity profile make it indispensable in the synthesis of complex bioactive molecules.
Specifications
| Molecular Formula | C9H14BN |
|---|---|
| Molecular Weight | 147.03 g/mol |
| Density | 0.86 g/cm³ |
| Boiling Point | 205.9°C at 760 mmHg |
| Melting Point | 172–175°C (lit.) |
| Refractive Index | 1.457 |
| Appearance | White powder |
| Assay | ≥98.0% |
| Water Content | ≤0.50% |
| Hazard Classification | Non-dangerous goods |
Industrial Applications
This borane derivative serves primarily as a versatile intermediate in the production of active pharmaceutical ingredients (APIs). It is notably utilized in synthetic pathways for steroidal therapeutics and other complex organic architectures requiring regioselective functionalization. Key advantages include:
- Enables efficient construction of biaryl and heterobiaryl motifs prevalent in drug candidates
- Offers excellent compatibility with palladium-catalyzed coupling protocols
- Provides high atom economy and reproducible yields under standard process conditions
- Supports scalable manufacturing with consistent batch-to-batch quality
Stored in a cool, dry, and well-ventilated environment with containers tightly sealed to prevent moisture ingress, Diethyl(3-pyridyl)borane is typically supplied in 25 kg drums, with custom packaging available upon request.
