Diethyl difluoromalonate
- CAS No.680-65-9
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity Diethyl Difluoromalonate (CAS 680-65-9) serving as a critical fluorinated building block for pharmaceutical and agrochemical synthesis.
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Product Overview
Diethyl difluoromalonate is a specialized organofluorine compound that plays a pivotal role in modern synthetic chemistry. As a fluorinated derivative of malonic acid ester, this reagent introduces valuable difluoro methylene groups into complex molecular architectures. The incorporation of fluorine atoms often enhances the metabolic stability, lipophilicity, and bioavailability of final pharmaceutical agents. Our grade is manufactured under strict quality control protocols to ensure consistency for research and industrial scale applications.
We understand the critical nature of supply chain reliability in the fine chemical sector. Shanghai Fluorine Technology provides a comprehensive platform for fluorinated intermediates, supporting clients from early-stage research to commercial production. This product is particularly valued for its reactivity in nucleophilic substitution and condensation reactions, making it indispensable for medicinal chemistry programs.
Technical Specifications
| Parameter | Value |
|---|---|
| CAS Number | 680-65-9 |
| Molecular Formula | C7H10F2O4 |
| Molecular Weight | 196.15 g/mol |
| Density | 1.179 g/cm3 |
| Boiling Point | 94-95°C at 23 mmHg |
| Refractive Index | 1.38 |
| Purity | ≥ 98.0% (GC) |
Industrial Applications
The versatility of Diethyl difluoromalonate extends across multiple high-value industries. Its primary utility lies in the construction of fluorinated heterocycles and carbon chains which are prevalent in modern drug discovery. The specific electronic properties imparted by the gem-difluoro group allow chemists to fine-tune the pKa and steric environment of target molecules.
- Pharmaceutical Intermediates: Used in the synthesis of novel therapeutic agents requiring fluorine substitution for improved pharmacokinetics.
- Agrochemical Development: Essential building block for creating next-generation pesticides with enhanced environmental stability.
- New Materials Science: Applied in the development of specialized polymers and functional materials requiring fluorinated backbones.
Quality Assurance and Storage
Every batch undergoes rigorous analytical testing including GC, NMR, and KF titration to verify identity and purity. We provide full documentation including Certificates of Analysis (COA) and Method of Analysis (MOA) with each shipment. To maintain product integrity, store in a cool, dry, and well-ventilated area away from incompatible materials such as strong oxidizing agents. Containers should be kept tightly closed when not in use to prevent moisture absorption. Our logistics team ensures safe packaging compliant with international shipping regulations for chemical goods.
