Intermediates

Diethyl Fluoromalonate

  • CAS No.685-88-1
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

Diethyl Fluoromalonate is a high-purity fluorinated intermediate essential for pharmaceutical and agrochemical synthesis. Available in bulk with comprehensive quality documentation.

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Product Technical Details

Product Overview

Diethyl Fluoromalonate represents a critical advancement in modern organic synthesis, serving as a versatile fluorinated building block for complex molecular construction. As a key member of the fluoromalonic acid ester family, this compound introduces stable carbon-fluorine bonds into target structures, significantly enhancing metabolic stability and bioavailability in final pharmaceutical products. Our facility specializes in the production of high-grade fluorinated intermediates, ensuring consistent quality for demanding research and industrial applications.

The incorporation of fluorine atoms into organic molecules is a strategic approach in medicinal chemistry to modulate physicochemical properties. Diethyl Fluoromalonate facilitates this process efficiently, acting as a precursor for various heterocyclic compounds and active pharmaceutical ingredients. Its unique reactivity profile allows for selective transformations, making it indispensable for synthetic chemists developing next-generation therapeutics and advanced agrochemical formulations.

Technical Specifications

ParameterSpecification
Product NameDiethyl Fluoromalonate
CAS Number685-88-1
Molecular FormulaC7H11FO4
Molecular Weight178.16 g/mol
AppearanceTransparent colorless to light yellow liquid
Density1.129 g/mL at 25 °C
Boiling Point121-122 °C at 30 mm Hg
Flash Point144 °F
Refractive Indexn20/D 1.407
Purity≥ 98.0% (GC)

Industrial Applications

This fluorinated intermediate finds extensive utility across multiple high-value sectors. In pharmaceutical research and development, it is utilized to synthesize enzyme inhibitors and receptor modulators where fluorine substitution improves binding affinity and metabolic resistance. The compound is particularly valuable in the development of anticancer agents and central nervous system therapeutics where precise structural modification is required.

Beyond healthcare, Diethyl Fluoromalonate serves as a vital component in agrochemical innovation. It contributes to the creation of novel pesticides and herbicides with enhanced environmental profiles and efficacy. Additionally, the material science sector leverages this chemical for producing specialized polymers and coatings with superior thermal and chemical resistance properties. Our supply chain supports diverse synthesis routes, accommodating both small-scale laboratory research and large-scale commercial manufacturing needs.

Quality Assurance And Supply Chain

Our company operates a comprehensive fluorochemical platform dedicated to delivering exceptional product consistency and reliability. Every batch of Diethyl Fluoromalonate undergoes rigorous quality control testing using advanced analytical techniques including Gas Chromatography, Nuclear Magnetic Resonance, and High-Performance Liquid Chromatography. We provide complete documentation packages with each shipment, including Certificates of Analysis, Safety Data Sheets, and method validation reports to ensure regulatory compliance.

We maintain robust inventory levels to guarantee timely fulfillment of global orders. Our logistics network supports secure packaging and temperature-controlled shipping where necessary to preserve product integrity during transit. Clients benefit from our technical support team, which offers guidance on storage conditions, handling procedures, and optimal synthesis protocols. By integrating raw material procurement, production, and quality control under one management system, we ensure a seamless supply experience for partners worldwide seeking dependable fluorinated chemical solutions.