(Difluoromethoxy)benzene
- CAS No.458-92-4
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity (Difluoromethoxy)benzene (CAS 458-92-4), a key fluorinated intermediate for advanced organic synthesis in pharmaceutical and agrochemical manufacturing.
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Product Overview
(Difluoromethoxy)benzene, also known as difluoromethyl phenyl ether, is a valuable fluorinated aromatic compound widely employed as a building block in modern organic synthesis. With the CAS number 458-92-4 and molecular formula C7H6F2O, this colorless transparent liquid offers unique reactivity due to the electron-withdrawing yet lipophilic nature of the difluoromethoxy group. Its strategic incorporation enhances metabolic stability and membrane permeability in complex molecule design, making it indispensable in the development of active pharmaceutical ingredients (APIs) and crop protection agents.
Specifications
| Molecular Formula | C7H6F2O |
|---|---|
| Molecular Weight | 144.119 g/mol |
| Appearance | Colorless transparent liquid |
| Assay | ≥98.0% |
| Density | 1.2 ± 0.1 g/cm³ |
| Boiling Point | 138.0 ± 25.0 °C at 760 mmHg |
| Flash Point | 43.1 ± 19.0 °C |
| Vapour Pressure | 8.5 ± 0.2 mmHg at 25°C |
| Refractive Index | 1.445 |
Industrial Applications
As a specialty fluorochemical intermediate, (difluoromethoxy)benzene serves critical roles in multi-step syntheses across the life sciences sector. Key applications include:
- Construction of fluorinated scaffolds in drug discovery programs targeting CNS disorders, oncology, and infectious diseases.
- Synthesis of novel agrochemicals where enhanced environmental persistence and bioavailability are required.
- Use as a precursor in the preparation of more complex aryl difluoromethyl ethers via cross-coupling or electrophilic substitution.
Stored in a cool, well-ventilated area away from ignition sources, this intermediate is typically supplied in 200 kg drums or customized packaging to meet global regulatory and logistical standards. Our manufacturing process ensures consistent industrial-grade purity with full documentation including Certificate of Analysis (COA).
