Ethyl 2,4,5-trifluorobenzoylacetate
- CAS No.98349-24-7
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity pharmaceutical intermediate essential for Delafloxacin synthesis, offering superior stability and reactivity for large-scale production.
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Product Overview
Ethyl 2,4,5-trifluorobenzoylacetate represents a critical building block in the modern pharmaceutical landscape, specifically designed for the synthesis of advanced fluoroquinolone antibiotics. As a fluorinated beta-keto ester, this compound exhibits exceptional chemical stability and reactivity, making it an indispensable precursor in the manufacturing of Delafloxacin. Our facility specializes in the production of high-grade organic intermediates that meet rigorous international standards, ensuring consistency and reliability for downstream pharmaceutical applications.
The introduction of multiple fluorine atoms at the 2, 4, and 5 positions of the benzoyl ring significantly enhances the metabolic stability and bioavailability of the final drug product. This strategic molecular architecture allows medicinal chemists to optimize pharmacokinetic profiles effectively. We understand the complexities involved in fine chemical synthesis and provide a product that minimizes impurity profiles while maximizing yield in subsequent coupling reactions.
Technical Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 98349-24-7 |
| Molecular Formula | C11H9F3O3 |
| Molecular Weight | 246.183 g/mol |
| Appearance | White powder |
| Assay (Purity) | ≥99.0% |
| Melting Point | 65-72°C |
| Moisture Content | ≤1.0% |
| Single Impurity | ≤0.5% |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 283.1±35.0 °C at 760 mmHg |
Industrial Applications
Primarily utilized as a key intermediate in the production of Delafloxacin, this compound plays a vital role in the development of next-generation antibacterial therapies. The high purity level ensures that downstream synthesis steps proceed without contamination, reducing the need for extensive purification later in the process. Beyond antibiotic synthesis, this fluorinated ester serves as a valuable reagent in organic chemistry research, particularly for projects requiring robust electron-withdrawing groups to modulate reaction kinetics.
Our manufacturing process is optimized for scalability, allowing us to support both pilot-scale research and commercial-grade production volumes. We employ advanced analytical techniques, including HPLC and NMR spectroscopy, to verify the structural integrity and purity of every batch. This commitment to quality control guarantees that our clients receive materials that perform predictably in their specific synthetic routes.
Quality Assurance and Advantages
- Consistent high purity levels exceeding 99.0% to ensure reaction efficiency.
- Strict control over moisture content to prevent hydrolysis during storage.
- Comprehensive documentation including COA, MSDS, and batch records.
- Flexible packaging solutions tailored to client logistics and safety requirements.
- Global supply chain capabilities ensuring timely delivery worldwide.
Storage and Handling
To maintain optimal chemical stability, Ethyl 2,4,5-trifluorobenzoylacetate should be stored in a cool, ventilated environment away from direct sunlight and moisture sources. Containers must be kept tightly sealed when not in use to prevent exposure to atmospheric humidity. Standard laboratory safety protocols should be followed during handling, including the use of appropriate personal protective equipment. By adhering to these storage guidelines, the shelf life and performance characteristics of the product are preserved effectively for long-term use.
