Ethyl 2-BOC-aminothiazole-5-carboxylate
- CAS No.302964-01-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity pharmaceutical intermediate used in the synthesis of kinase inhibitors. Available in bulk quantities with comprehensive quality documentation.
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Product Overview
Ethyl 2-BOC-aminothiazole-5-carboxylate represents a critical heterocyclic building block within the realm of modern medicinal chemistry. This specialized compound features a thiazole core protected by a tert-butoxycarbonyl (BOC) group, rendering it highly stable and versatile for complex organic synthesis. As a key precursor, it plays an indispensable role in the construction of advanced pharmaceutical agents, particularly within the oncology sector where precision and purity are paramount.
Our manufacturing process ensures that every batch meets rigorous international standards. The chemical structure facilitates selective reactions, allowing medicinal chemists to efficiently build complex molecular architectures required for next-generation therapeutics. The presence of the ester functionality further enhances its utility in diverse synthetic pathways, making it a preferred choice for research and development teams globally.
Chemical Properties and Specifications
Understanding the physicochemical profile of this intermediate is essential for optimal handling and reaction planning. The compound exhibits excellent stability under standard storage conditions, provided moisture is controlled. The high melting point indicates strong crystalline structure, which aids in purification processes such as recrystallization. Below are the detailed technical specifications verified through our quality control laboratories.
| Parameter | Specification |
|---|---|
| Chemical Name | Ethyl 2-BOC-aminothiazole-5-carboxylate |
| CAS Number | 302964-01-8 |
| Molecular Formula | C11H16N2O4S |
| Molecular Weight | 272.321 g/mol |
| Appearance | Light yellow to yellow powder |
| Assay (HPLC) | ≥98.0% |
| Moisture Content | ≤0.5% |
| Density | 1.3±0.1 g/cm3 |
| Melting Point | >300ºC |
Industrial Applications
This intermediate is primarily utilized in the synthesis of kinase inhibitors, which are vital components in targeted cancer therapies. Specifically, it serves as a crucial building block for the production of Dasatinib, a potent tyrosine kinase inhibitor used in treating certain types of leukemia. The high purity of our material ensures that downstream API synthesis proceeds with minimal impurity carryover, thereby reducing purification costs and improving overall yield.
Beyond oncology, the thiazole scaffold is increasingly relevant in the development of agents targeting various enzymatic pathways. The BOC protection group allows for orthogonal deprotection strategies, enabling multi-step synthesis routes without compromising the integrity of the amine functionality. This flexibility makes the compound suitable for both large-scale manufacturing and custom research projects.
Quality Assurance and Handling
Quality is the cornerstone of our production philosophy. Each lot undergoes comprehensive analysis using High-Performance Liquid Chromatography (HPLC) and Nuclear Magnetic Resonance (NMR) spectroscopy. We provide a Certificate of Analysis (COA) with every shipment, detailing all critical quality attributes. Our facilities adhere to strict safety and environmental protocols, ensuring consistent supply chain reliability.
For optimal stability, store this product in a cool, ventilated area away from direct sunlight and moisture sources. The material should be kept in tightly sealed containers to prevent hydrolysis of the ester group. We offer flexible packaging options, including 25 kg drums, and can accommodate custom requirements based on project scale. Contact our technical sales team for detailed safety data sheets and bulk pricing information.
