Ethyl 4,4,4-trifluoroacetoacetate
- CAS No.372-31-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity Ethyl 4,4,4-trifluoroacetoacetate (CAS 372-31-6) designed for pharmaceutical synthesis. Reliable bulk supply with comprehensive COA documentation.
Request Bulk PricingProduct Technical Details
Product Overview
Ethyl 4,4,4-trifluoroacetoacetate represents a critical fluorinated building block within the realm of advanced organic synthesis. As a specialized intermediate, it serves as a foundational component for constructing complex molecular architectures required in modern pharmaceutical development. Our facility produces this compound under strict quality control standards to ensure consistency across batches, making it an ideal choice for research laboratories and industrial manufacturing scales alike.
The introduction of the trifluoromethyl group into organic molecules often enhances metabolic stability and lipophilicity, which are desirable traits in medicinal chemistry. This specific ester provides a versatile reactive site for further chemical transformations, including condensation reactions and cyclization processes. We prioritize the delivery of high-purity materials to support efficient downstream synthesis without the need for extensive purification steps.
Technical Specifications
Quality assurance is paramount in the supply of fine chemical intermediates. Each batch undergoes rigorous analytical testing using gas chromatography and other standard methods to verify compliance with specified parameters. The physical properties listed below are typical values obtained from our quality control laboratory.
| Parameter | Specification |
|---|---|
| CAS Number | 372-31-6 |
| Molecular Formula | C6H7F3O3 |
| Molecular Weight | 184.11 g/mol |
| Appearance | Colorless transparent liquid |
| Purity | ≥98.0% |
| Moisture Content | ≤0.1% |
| Boiling Point | 129-130 °C |
| Density | 1.259 g/cm3 |
| Refractive Index | 1.363 |
Industrial Applications
This fluorinated beta-keto ester is primarily utilized in the manufacture of active pharmaceutical ingredients. It acts as a key intermediate in the synthesis of various therapeutic agents, including anticonvulsant medications. The chemical structure allows for specific functionalization that is essential in creating the pharmacophore of complex drug molecules. Beyond pharmaceuticals, it may also find applications in agrochemical research and materials science where fluorinated motifs are required.
Chemists value this reagent for its reactivity profile and stability under standard storage conditions. It facilitates the introduction of trifluoromethyl groups into target molecules, which can significantly alter the biological activity and pharmacokinetic properties of the final compound. Our team supports customers with technical data to ensure safe and effective integration into their specific synthesis routes.
Storage and Packaging
To maintain optimal quality, Ethyl 4,4,4-trifluoroacetoacetate should be stored in a cool and dry environment. Containers must remain well-closed to prevent exposure to moisture and strong light or heat sources. We offer flexible packaging solutions to meet diverse logistical needs, including standard 25kg cardboard drums or custom configurations based on client requirements. Global shipping capabilities ensure timely delivery to manufacturing sites worldwide.
Our commitment to safety and compliance extends to all documentation provided. Customers receive a Certificate of Analysis with every shipment, detailing the specific test results for the purchased lot. For large-scale projects, we offer competitive bulk pricing and dedicated account management to streamline the procurement process. Contact our sales team for current availability and technical inquiries regarding this specialized chemical intermediate.
