Ethyl 4,4-Difluoroacetoacetate

Product Overview

Ethyl 4,4-Difluoroacetoacetate (CAS 352-24-9) is a high-value fluorinated organic intermediate featuring a reactive β-ketoester scaffold with two geminal fluorine atoms. This unique structure imparts enhanced metabolic stability, lipophilicity, and electronic properties, making it an indispensable synthon in modern medicinal chemistry and crop protection agent development. As a specialized fluorochemical building block, it enables the efficient construction of complex fluorinated molecular architectures under mild reaction conditions.

Specifications

Industrial Applications

This compound serves primarily as a strategic intermediate in the synthesis of active pharmaceutical ingredients (APIs) and novel agrochemicals. Its dual functionality—comprising both a ketone and an ester group adjacent to a difluoromethylene unit—allows for diverse transformations, including Knoevenagel condensations, Michael additions, and heterocycle formations. Key application areas include:

• Construction of fluorinated pyrazoles, isoxazoles, and other nitrogen-containing heterocycles prevalent in drug candidates.
• Synthesis of enzyme inhibitors where the CF2 group mimics carbonyl or methylene motifs with improved bioavailability.
• Development of next-generation pesticides leveraging fluorine’s ability to enhance target binding and environmental persistence profiles.

As part of a comprehensive fluorochemical portfolio, Ethyl 4,4-Difluoroacetoacetate supports innovation in advanced organic synthesis, offering researchers a reliable, high-purity reagent for cutting-edge discovery programs.