Ethyl 5,7-Difluoro-1H-indole-2-carboxylate
- CAS No.220679-10-7
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity Ethyl 5,7-difluoro-1H-indole-2-carboxylate (CAS 220679-10-7), a key fluorinated indole intermediate for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
Ethyl 5,7-difluoro-1H-indole-2-carboxylate is a high-value fluorinated heterocyclic building block widely employed as an intermediate in modern organic synthesis. With its dual fluorine substitution pattern on the indole core, this compound offers enhanced metabolic stability and electronic modulation, making it particularly valuable in the development of novel bioactive molecules for pharmaceutical and agrochemical applications.
Specifications
| Molecular Formula | C₁₁H₉F₂NO₂ |
|---|---|
| Molecular Weight | 225.191 g/mol |
| Density | 1.4 ± 0.1 g/cm³ |
| Boiling Point | 342.5 ± 37.0 °C at 760 mmHg |
| Flash Point | 160.9 ± 26.5 °C |
| Vapour Pressure | 0.0 ± 0.8 mmHg at 25 °C |
| Refractive Index | 1.581 |
| Appearance | White powder |
| Assay | ≥97.0% |
Industrial Applications
This fluorinated indole derivative serves primarily as a specialized intermediate in multi-step synthetic routes. Its structural features enable efficient construction of complex molecular architectures, including kinase inhibitors, serotonin receptor modulators, and other neurologically active scaffolds. Due to the electron-withdrawing nature of the fluorine atoms, it facilitates regioselective functionalization at C-3 or N-1 positions under mild conditions.
- Ideal for medicinal chemistry campaigns requiring fluorine-enhanced pharmacokinetics
- Suitable for Suzuki, Buchwald-Hartwig, and other cross-coupling transformations
- Compatible with standard peptide and small-molecule synthesis workflows
Stored in a cool, well-ventilated area away from moisture and oxidizing agents, the product maintains stability for extended periods. Standard packaging is 25 kg per drum, with custom options available upon request to meet GMP or research-scale requirements.
