Intermediates

Ethyl 6-bromopyridine-2-carboxylate

  • CAS No.21190-88-5
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

Ethyl 6-bromopyridine-2-carboxylate is a high-purity pyridine derivative used extensively in pharmaceutical and agrochemical synthesis. Available in bulk with strict quality control.

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Product Technical Details

Product Overview

Ethyl 6-bromopyridine-2-carboxylate stands as a pivotal heterocyclic building block within the realm of advanced organic synthesis. Characterized by its unique pyridine backbone substituted with a bromine atom at the sixth position and an ethyl ester group at the second position, this compound offers exceptional versatility for medicinal chemists. Our facility produces this reagent under stringent quality controls to ensure consistent batch-to-batch reliability, making it an ideal choice for complex multi-step synthesis pathways required in modern drug discovery programs. The molecular stability and defined reactivity profile make it a preferred choice for research and development teams focusing on novel compound generation.

The chemical structure facilitates a wide array of transformation reactions, particularly palladium-catalyzed cross-couplings such as Suzuki, Heck, and Sonogashira reactions. The electron-withdrawing nature of the ester group combined with the halogen handle allows for precise functionalization, enabling the construction of sophisticated molecular architectures. This reactivity profile is essential for developing novel pharmaceutical active ingredients where specific spatial arrangement and electronic properties are critical for biological activity. Our manufacturing process optimizes yield while minimizing side products, ensuring a clean starting material for sensitive downstream processes.

Technical Specifications

ParameterValue
Chemical NameEthyl 6-bromopyridine-2-carboxylate
CAS Number21190-88-5
Molecular FormulaC8H8BrNO2
Molecular Weight230.06 g/mol
AppearanceWhite to off-white powder
Assay≥98.0%
Moisture Content≤0.5%
Melting Point41-42ºC
Boiling Point302.7ºC
Density1.501 g/cm3

Industrial Applications

Primarily utilized as a key intermediate in the pharmaceutical industry, this compound serves as a precursor for various kinase inhibitors and anti-inflammatory agents. Beyond human health applications, it finds significant utility in agrochemical synthesis, contributing to the development of next-generation fungicides and herbicides. The high purity grade we supply ensures minimal impurity carryover, which is vital for maintaining the integrity of downstream processes and final product safety profiles. Researchers value this material for its ability to introduce specific nitrogen-containing heterocycles into larger molecular frameworks efficiently.

  • Pharmaceutical API synthesis and drug discovery
  • Agrochemical active ingredient development
  • Material science and functional polymer research
  • Custom organic synthesis projects

Quality Assurance and Logistics

We adhere to international quality management standards, providing comprehensive Certificates of Analysis with every shipment. Our packaging solutions are designed to maintain stability during transit, utilizing moisture-resistant drums that protect the integrity of the white to off-white powder. With a global supply chain network, we guarantee timely delivery and competitive bulk pricing structures tailored to meet the demands of large-scale industrial manufacturing partners worldwide. Storage recommendations include keeping the material in a cool, ventilated place away from direct sunlight and moisture to preserve its chemical properties over extended periods.