Ethyl 7-Chloro-2-oxoheptanoate
- CAS No.78834-75-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity Ethyl 7-Chloro-2-oxoheptanoate (CAS 78834-75-0), a key pharmaceutical intermediate for Cilastatin synthesis.
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Product Overview
Ethyl 7-Chloro-2-oxoheptanoate is a high-value organic building block widely employed in the pharmaceutical industry as a critical synthetic intermediate. With a molecular formula of C9H15ClO3 and a molecular weight of 206.67 g/mol, this compound features a reactive keto group and a terminal chloro functionality, making it highly versatile for multi-step syntheses. It is primarily utilized in the production of Cilastatin (CAS 82009-34-5), a renal dehydropeptidase inhibitor often co-administered with antibiotics to enhance their therapeutic efficacy.
Specifications
| Molecular Formula | C9H15ClO3 |
|---|---|
| Molecular Weight | 206.667 g/mol |
| Exact Mass | 206.071 |
| Density | 1.093 g/cm³ |
| Boiling Point | 281.2°C at 760 mmHg |
| Flash Point | 111.3°C |
| Refractive Index | 1.445 |
| LogP | 1.918 |
| PSA | 43.37 Ų |
| Appearance | Light green to slightly yellow clear liquid |
| Assay (GC) | ≥99.0% |
| Single Impurity (GC) | ≤0.5% |
| Storage Condition | -70°C; store in a cool, dry, and well-ventilated area with container tightly closed |
Industrial Applications
This compound serves exclusively as a chemical intermediate in advanced pharmaceutical manufacturing. Its primary application lies in the synthesis of Cilastatin, where it contributes to the construction of the molecule’s core structure through controlled alkylation and cyclization steps. Due to its high reactivity and stringent purity requirements, Ethyl 7-Chloro-2-oxoheptanoate is handled under strict quality control protocols to ensure batch-to-batch consistency and compliance with ICH guidelines.
- Essential precursor for Cilastatin active pharmaceutical ingredient (API)
- Enables efficient carbon-chain elongation in complex syntheses
- Supplied in industrial-scale packaging (25 kg/drum) with custom options available
- Manufactured under ISO-compliant processes with full documentation (COA, SDS)
