Intermediates

Ethyl Chlorodifluoroacetate

  • CAS No.383-62-0
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

Premium grade Ethyl Chlorodifluoroacetate (CAS 383-62-0) for pharmaceutical and agrochemical synthesis. High purity fluorinated intermediate available in bulk.

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Product Technical Details

Product Overview

Ethyl Chlorodifluoroacetate is a highly valued fluorinated organic intermediate characterized by its unique chemical structure containing both chlorine and fluorine substituents on the acetate backbone. As a critical building block in modern organic synthesis, this compound serves as an essential reagent for introducing difluoromethylene groups into complex molecular architectures. Our facility specializes in the production of high-purity fluorochemicals, ensuring that every batch meets rigorous international standards for pharmaceutical and industrial applications.

The strategic incorporation of fluorine atoms into organic molecules is a cornerstone of contemporary medicinal chemistry and material science. This specific ester provides chemists with a reliable pathway to enhance the metabolic stability, lipophilicity, and bioavailability of target compounds. Whether utilized in the development of novel active pharmaceutical ingredients or the formulation of advanced agrochemicals, Ethyl Chlorodifluoroacetate offers superior reactivity and consistency.

Key Specifications

ParameterValue
CAS Number383-62-0
Molecular FormulaC4H5ClF2O2
Molecular Weight158.53 g/mol
AppearanceTransparent colorless liquid
Density1.252 g/mL at 25 °C
Boiling Point96-97.5 °C
Flash Point65 °F
Refractive Indexn20/D 1.358

Industrial Applications

This fluorinated ester finds extensive utility across multiple high-tech sectors. In the pharmaceutical industry, it is employed as a key intermediate for synthesizing compounds that require enhanced metabolic resistance against oxidative enzymes. The presence of fluorine atoms often acts as a bioisostere for hydrogen or hydroxyl groups, significantly improving the pharmacokinetic profile of drug candidates.

In the agrochemical sector, Ethyl Chlorodifluoroacetate is utilized in the development of new pesticides and herbicides. The fluorine content contributes to the environmental stability and efficacy of these products, allowing for lower application rates and improved performance under varying field conditions. Additionally, it serves as a vital precursor in the synthesis of new materials, including polymers and liquid crystals, where specific electronic and physical properties are required.

Quality Assurance and Advantages

  • High Purity Standards: Manufactured under strict quality control protocols to ensure minimal impurities.
  • Consistent Supply Chain: Robust production capacity guarantees reliable delivery for large-scale industrial needs.
  • Technical Support: Comprehensive documentation including COA, MSDS, and synthetic route guidance is available.
  • Customization: Flexible packaging and synthesis options to meet specific research and production requirements.

Storage and Handling

To maintain optimal quality, Ethyl Chlorodifluoroacetate should be stored in a cool, dry, and well-ventilated area away from direct sunlight and heat sources. Containers must be kept tightly closed to prevent moisture absorption and contamination. Proper personal protective equipment, including gloves and safety goggles, should be worn during handling to ensure safety in accordance with standard laboratory and industrial hygiene practices. Our commitment to safety and quality makes us a trusted partner for global fluorchemical procurement.