Ethyl Cyanoglyoxylate-2-Oxime
- CAS No.3849-21-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
Premium grade Ethyl cyanoglyoxylate-2-oxime designed for efficient peptide coupling and organic synthesis. Available in bulk with certified high purity.
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Product Overview
Ethyl cyanoglyoxylate-2-oxime, widely recognized in the industry as Oxyma, represents a critical advancement in modern organic synthesis and peptide coupling technologies. As a highly effective condensation reagent additive, this compound serves as a superior alternative to traditional benzotriazole-based additives, offering enhanced safety profiles without compromising reaction efficiency. Our manufacturing process ensures consistent quality suitable for large-scale pharmaceutical and chemical production environments.
This specialized intermediate is engineered to suppress racemization during peptide bond formation, making it indispensable for the synthesis of complex pharmaceutical APIs and advanced organic structures. The chemical stability and solubility characteristics of Ethyl cyanoglyoxylate-2-oxime facilitate smoother reaction workflows, reducing side reactions and improving overall yield in multi-step synthesis routes.
Key Chemical Properties
The physical and chemical attributes of this compound are meticulously controlled to meet rigorous international standards. With a molecular formula of C5H6N2O3 and a molecular weight of 142.11, it exhibits optimal reactivity under standard coupling conditions. The material presents as a light yellow to white crystalline solid, ensuring easy handling and accurate weighing in laboratory and industrial settings.
- High thermal stability with a melting point range of 130-132 degrees Celsius.
- Low sensitivity to shock and friction compared to historical alternatives like HOBt.
- Excellent solubility in common organic solvents used in peptide synthesis.
- Minimal risk of explosion, enhancing workplace safety during storage and transport.
Industrial Applications
Primarily utilized as a condensation reagent, Ethyl cyanoglyoxylate-2-oxime is a cornerstone in the manufacture of bioactive peptides and fine chemicals. It is frequently employed in conjunction with carbodiimides to activate carboxylic acids, enabling efficient amide bond formation. This functionality is crucial for researchers and manufacturers developing neurological therapeutics, complex pharmaceutical APIs, and advanced organic synthesis projects where stereochemical integrity is paramount.
Beyond peptide synthesis, this intermediate finds application in the production of specialty polymers and agrochemical intermediates. Its ability to minimize epimerization makes it a preferred choice for synthesizing chiral molecules where optical purity is a critical quality attribute.
Quality Specifications
We adhere to strict quality control protocols to ensure every batch meets or exceeds factory standards. The following table outlines the key analytical parameters for our standard grade product:
| Parameter | Specification |
|---|---|
| Appearance | Light yellow to off-white crystal |
| Identification | HNMR conforms to reference standard |
| Purity (HPLC) | ≥99.0% |
| Melting Point | 127-132 degrees Celsius |
| Residue on Ignition | ≤0.5% |
| Loss on Drying | ≤1.0% |
Packaging and Storage
To maintain integrity during transit, Ethyl cyanoglyoxylate-2-oxime is packaged in 25 kg drums, with custom packaging solutions available upon request. Proper storage involves keeping the material in a cool, ventilated area away from direct sunlight and moisture. As a global manufacturer, we provide comprehensive documentation including Certificates of Analysis (COA) with every shipment to support regulatory compliance and quality assurance audits.
