(S)-Ethyl-N-Boc-pyroglutamate
- CAS No.144978-12-1
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity pharmaceutical intermediate for Saxagliptin synthesis. Available in bulk with COA.
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Product Overview
(S)-Ethyl-N-Boc-pyroglutamate is a highly specialized chiral building block extensively utilized in the pharmaceutical industry for the synthesis of complex active pharmaceutical ingredients. This compound features a protected pyrrolidine structure with a tert-butoxycarbonyl (Boc) group, which ensures stability during various chemical transformations. The ethyl ester functionality provides excellent solubility profiles suitable for diverse reaction conditions. As a key intermediate, it plays a pivotal role in constructing the core scaffold of DPP-4 inhibitors, specifically contributing to the production of antidiabetic medications.
Our manufacturing process emphasizes strict stereochemical control to maintain the (S)-configuration, which is essential for the biological activity of the final drug product. The high optical purity ensures minimal downstream purification requirements, thereby optimizing overall synthesis efficiency for our partners. We employ advanced chromatographic techniques and rigorous quality control protocols to guarantee consistency across every batch produced.
Chemical Specifications
| Parameter | Value |
|---|---|
| CAS Number | 144978-12-1 |
| Molecular Formula | C12H19NO5 |
| Molecular Weight | 257.283 g/mol |
| Appearance | White powder |
| Assay | ≥98.0% |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 375.0±35.0 °C at 760 mmHg |
| Flash Point | 180.6±25.9 °C |
Industrial Applications
The primary application of this compound lies in the manufacturing of Saxagliptin, a prominent medication used for the management of type 2 diabetes. The structural integrity provided by the Boc protection group allows for selective reactions at the carboxylate position without compromising the amine functionality. This selectivity is crucial for multi-step synthesis routes where orthogonal protection strategies are required.
- Essential intermediate for DPP-4 inhibitor synthesis
- Compatible with various peptide coupling reagents
- Stable under standard storage and handling conditions
- Facilitates efficient scale-up for commercial production
Quality Assurance and Storage
We adhere to international quality standards to ensure that every shipment meets the stringent requirements of pharmaceutical manufacturers. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing physical and chemical properties. Proper storage is vital to maintain product integrity over time. We recommend storing the material in a cool, ventilated environment away from direct sunlight and moisture. Packaging options include 25 kg drums, with customization available to suit specific logistical needs. Our global supply chain ensures timely delivery while maintaining the cold chain or protective packaging necessary for sensitive chemical intermediates.
