Intermediates

1H-Indazole-3-carboxylic Acid

  • CAS No.4498-67-3
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity Indazole-3-carboxylic Acid (CAS 4498-67-3) for pharmaceutical API synthesis. Reliable supply with comprehensive COA and global shipping options available.

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Product Technical Details

Product Overview

Indazole-3-carboxylic acid, systematically recognized as 1H-Indazole-3-carboxylic Acid, represents a critical heterocyclic building block within the modern pharmaceutical landscape. This organic compound features an indazole core substituted with a carboxylic acid group, providing unique reactivity profiles essential for complex molecular construction. Our facility specializes in the large-scale production of this key intermediate, ensuring consistent supply chains for global API manufacturers who demand reliability and precision.

The compound serves as a foundational precursor in the synthesis of various therapeutic agents. Its structural integrity and high purity levels are paramount for ensuring the efficacy and safety of downstream pharmaceutical products. We adhere to strict manufacturing protocols to maintain the chemical stability and performance benchmarks required by industrial partners engaged in advanced organic synthesis.

Technical Specifications

Quality control is the cornerstone of our production process. Each batch undergoes rigorous analytical testing to verify compliance with established standards. The following table outlines the key physical and chemical parameters guaranteed for our commercial grade material, ensuring it meets the demanding requirements of pharmaceutical production.

Items of AnalysisStandardTypical Results
AppearanceLight yellow to off-white powderConform
Assay (HPLC)≥98.0%99.12%
Melting Point259-265°C261.8-262.5°C
Sulphated Ash≤0.5%0.09%
Moisture≤0.5%0.09%
ConclusionConforms to Factory Standard

Industrial Applications

Primarily utilized as an intermediate in the manufacturing of prescription medications, this chemical plays a vital role in the production of antiemetic agents such as Granisetron hydrochloride. The high purity specification minimizes side reactions during coupling steps, thereby optimizing overall yield and reducing purification burdens in subsequent synthesis stages. This efficiency is crucial for cost-effective large-scale manufacturing.

Beyond specific API production, Indazole-3-carboxylic acid is valuable in medicinal chemistry research and development. It facilitates the exploration of new biological activities associated with the indazole scaffold. Our material supports both commercial scale-up and early-stage process development initiatives, providing a reliable foundation for innovation in neurological and therapeutic chemistry.

Quality Assurance and Testing

We implement a comprehensive quality management system to monitor every stage of production. Impurity profiles are closely tracked using high-performance liquid chromatography (HPLC). Parameters such as sulphated ash, loss on drying, and specific impurities like Indazole and Isatin are controlled within tight limits to ensure product reliability and safety for downstream processing.

Certificates of Analysis (COA) are provided with every shipment, detailing actual test results against standard specifications. This transparency allows our clients to validate material quality upon receipt and integrate it seamlessly into their manufacturing workflows without additional qualification delays. Our commitment to quality ensures batch-to-batch consistency.

Storage and Handling

To maintain optimal stability, the product should be stored in a cool and dry environment. Containers must remain well-closed to protect against moisture absorption and exposure to strong light or heat sources. Proper handling procedures ensure that the physical appearance and chemical properties remain unchanged throughout the shelf life, preserving the value of the material.

Packaging options include 25kg cardboard drums or customized solutions based on customer requirements. We offer global logistics support to deliver this essential chemical intermediate safely to laboratories and production facilities worldwide. Contact our sales team for detailed information regarding bulk pricing, lead times, and availability for your specific project needs.