Isobutyl Chloroformate
- CAS No.543-27-1
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity Isobutyl Chloroformate designed for pharmaceutical intermediate synthesis. Reliable supply with strict quality control and global logistics.
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Product Overview
Isobutyl Chloroformate is a highly versatile chemical reagent extensively utilized in the field of organic synthesis and pharmaceutical manufacturing. Known chemically as 2-methylpropyl carbonochloridate, this compound serves as a critical building block for constructing complex molecular structures. Our facility produces this intermediate under strict quality control protocols to ensure consistency and reliability for downstream applications.
With a molecular formula of C5H9ClO2 and a molecular weight of 136.58 g/mol, this colorless to light-colored liquid is characterized by its high reactivity in acylation reactions. It is particularly valued in the production of active pharmaceutical ingredients (APIs), where precision and purity are paramount. We commit to delivering a product that meets rigorous international standards for chemical intermediates, supporting both large-scale production and research development needs.
Technical Specifications
Quality assurance is the cornerstone of our manufacturing process. Each batch of Isobutyl Chloroformate undergoes comprehensive testing to verify physical and chemical properties. The following table outlines the key specifications guaranteed for our standard grade product, ensuring it meets the demands of sensitive synthetic pathways:
| Parameter | Specification |
|---|---|
| CAS Number | 543-27-1 |
| Appearance | Colorless To Light-colored Liquid |
| Purity | ≥99% |
| Total Impurity | 0.2% Max. |
| Heavy Metals | 10ppm Max |
| Density | 1.053 g/mL at 25 °C |
| Boiling Point | 128.8 °C |
| Refractive Index | n20/D 1.407 |
Industrial Applications
This chloroformate ester is primarily employed as an intermediate in the synthesis of sophisticated pharmaceutical compounds. It plays a vital role in introducing the isobutyloxycarbonyl protecting group or facilitating coupling reactions in multi-step synthesis routes. Notably, it is utilized in the manufacturing process of antiviral agents, including intermediates for protease inhibitors such as Nelfinavir mesylate.
- Pharmaceutical API synthesis and process development.
- Organic synthesis requiring high-purity acylation reagents.
- Production of fine chemicals and specialized intermediates.
- Research and development in medicinal chemistry laboratories.
Our global clientele relies on this material for its consistent performance in sensitive reaction conditions. The high purity level ensures minimal side reactions, optimizing yield and reducing purification burdens in final drug substance production. We support custom synthesis routes and provide technical documentation to facilitate seamless integration into your production line.
Storage and Handling
Proper storage is essential to maintain the stability and efficacy of Isobutyl Chloroformate. Due to its chemical nature, the product must be kept in a tightly closed container to prevent moisture ingress, which can lead to hydrolysis. We recommend storing the material in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizing agents, bases, and water.
The ideal storage temperature ranges between 2-8ºC. Personnel handling this chemical should adhere to standard safety protocols, including the use of appropriate personal protective equipment (PPE). Keep away from heat, sparks, and open flames due to its flash point of 82°F. Our packaging options include 25kg cardboard drums, customizable according to specific customer requirements to ensure safe global logistics and compliance with transportation regulations.
