L-Glutamic Acid 5-Methyl Ester
- CAS No.1499-55-4
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity L-Glutamic Acid 5-Methyl Ester (CAS 1499-55-4), ≥98%, widely used as a key chiral intermediate in pharmaceutical and peptide synthesis.
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Product Overview
L-Glutamic Acid 5-Methyl Ester (CAS 1499-55-4) is a chemically protected derivative of the naturally occurring nonessential amino acid L-glutamic acid. This compound serves as a versatile building block in organic and medicinal chemistry, particularly valued for its role in solid-phase peptide synthesis and as a precursor in the development of neuroactive pharmaceutical agents. With a molecular formula of C6H11NO4 and a molecular weight of 161.16 g/mol, it maintains the chiral integrity essential for stereospecific syntheses.
Specifications
| Molecular Formula | C6H11NO4 |
|---|---|
| Molecular Weight | 161.16 g/mol |
| Appearance | White powder |
| Purity | ≥98% |
| Chloride Content (Cl) | ≤0.05% |
| Loss on Drying | ≤0.50% |
| Melting Point | 182 °C (dec.) |
| Density | 1.242 g/cm³ |
| Boiling Point | 316.1 °C at 760 mmHg |
| Refractive Index | [α]²⁹D = +29° (c = 2, 6 mol/L HCl) |
Industrial Applications
As a gamma-esterified glutamate derivative, L-Glutamic Acid 5-Methyl Ester is primarily employed as a synthetic intermediate in the production of complex pharmaceutical active ingredients (APIs), especially those targeting neurological pathways. Its ester functionality allows for selective protection during multi-step syntheses, enabling precise control over reactivity in peptide coupling and side-chain modifications. While L-glutamic acid itself functions as a neurotransmitter in the central nervous system, this methyl ester form is not used directly in therapeutics but rather as a critical tool in R&D and GMP-compliant manufacturing processes.
- Ideal for chiral pool synthesis and asymmetric transformations
- Compatible with Fmoc/t-Boc strategies in peptide chemistry
- Stable under standard handling conditions when stored properly
- Meets stringent quality requirements for pharmaceutical intermediates
Storage & Handling
Store at 2–8 °C in a tightly sealed container, protected from moisture and light. Keep in a cool, dry environment. Standard industrial hygiene practices should be followed during handling. Packaging is typically 25 kg per drum, with custom options available upon request.
