L-Norleucine
- CAS No.327-57-1
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity L-Norleucine (CAS 327-57-1) for use as a chiral building block and pharmaceutical intermediate in API synthesis.
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Product Overview
L-Norleucine is a non-proteinogenic amino acid with the molecular formula C6H13NO2 and a molecular weight of 131.17 g/mol. It serves as a valuable chiral synthon in the development of complex active pharmaceutical ingredients (APIs) and peptide-based therapeutics. This compound is structurally analogous to leucine but features a linear hexanoic side chain, offering distinct steric and electronic properties beneficial in medicinal chemistry.
Specifications
| Molecular Formula | C6H13NO2 |
|---|---|
| Molecular Weight | 131.173 g/mol |
| Melting Point | 300°C |
| Specific Rotation [α]D20 | +23.5° to +24.5° (c=4, 6M HCl) |
| Assay | 98.5%–101.0% |
| Solubility in 3M HCl | Colorless and clear (c=4) |
| Loss on Drying | ≤0.3% |
| Residue on Ignition | ≤0.1% (as sulfate) |
| Heavy Metals (as Pb) | ≤10 ppm |
| Arsenic (As2O3) | ≤1 ppm |
| Other Amino Acids | Not detected by TLC (20 μg spotted) |
Industrial Applications
L-Norleucine is primarily employed as a high-value intermediate in the synthesis of advanced organic molecules, particularly within the pharmaceutical and biotechnology sectors. Its key applications include:
- Serving as a chiral building block in the construction of peptidomimetics and modified peptides.
- Acting as a structural surrogate for natural amino acids to enhance metabolic stability or bioavailability in drug candidates.
- Supporting research in enzyme inhibition studies and structure-activity relationship (SAR) modeling.
- Facilitating the development of novel neurological therapeutics through stereoselective synthesis routes.
Manufactured under stringent quality control protocols, our L-Norleucine meets international pharmacopeial standards and is suitable for GMP-compliant processes. The product is supplied in 25 kg fiber drums with custom packaging available upon request. Store in a cool, dry, and well-ventilated area with the container tightly sealed to maintain integrity and prevent moisture uptake.
