Methyl 1-(Mercaptomethyl)cyclopropaneacetate
- CAS No.152922-73-1
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity Methyl 1-(Mercaptomethyl)cyclopropaneacetate (CAS 152922-73-1), a key intermediate in the synthesis of Montelukast. Ideal for pharmaceutical manufacturing with ≥98% purity.
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Product Overview
Methyl 1-(Mercaptomethyl)cyclopropaneacetate is a high-value organic sulfur-containing building block widely employed as a critical intermediate in the synthesis of active pharmaceutical ingredients (APIs). With a CAS number of 152922-73-1 and molecular formula C7H12O2S, this compound features a strained cyclopropyl ring functionalized with both a thiol and an ester group, enabling versatile reactivity in multi-step synthetic sequences. It is particularly recognized for its role in the production of leukotriene receptor antagonists such as Montelukast.
Specifications
| Molecular Formula | C7H12O2S |
|---|---|
| Molecular Weight | 160.23 g/mol |
| Appearance | Light yellow to colorless liquid |
| Purity (GC) | ≥98% |
| Moisture Content | 0.02% |
| Density | 1.11 g/cm³ |
| Boiling Point | 208.9°C at 760 mmHg |
| Flash Point | 92.7°C |
| Refractive Index | 1.495 |
Industrial Applications
This compound serves exclusively as a chemical intermediate in advanced pharmaceutical synthesis. Its primary application lies in the construction of the side-chain moiety of Montelukast (CAS 158966-92-8), a widely prescribed anti-asthma medication. Due to its reactive mercaptomethyl group adjacent to a rigid cyclopropane scaffold, it facilitates selective carbon-sulfur bond formation under controlled conditions.
Key advantages for industrial users include:
- Consistent high purity (≥98%) ensuring reliable reaction yields
- Low moisture content minimizing side reactions during synthesis
- Stable liquid form enabling precise dosing in continuous manufacturing processes
- Compatibility with standard handling protocols for sensitive organosulfur compounds
Handling and Storage
Store in a tightly sealed container in a cool, dry, and well-ventilated area away from direct sunlight, heat sources, and oxidizing agents. Maintain under inert atmosphere if long-term storage is required. Standard personal protective equipment (PPE) including gloves and safety goggles should be used during handling.
