Intermediates

Methyl 2,2-Difluoro-2-(fluorosulfonyl)acetate

  • CAS No.680-15-9
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity methyl 2,2-difluoro-2-(fluorosulfonyl)acetate (CAS 680-15-9), a versatile fluorinated intermediate for pharmaceutical R&D and advanced material synthesis.

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Product Technical Details

Product Overview

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate is a specialized fluorinated organic compound widely employed as a key building block in modern synthetic chemistry. With its unique combination of difluoro and fluorosulfonyl functional groups, this reagent serves as a valuable precursor in the development of novel fluorine-containing molecules for pharmaceuticals, agrochemicals, and advanced materials. As a high-reactivity intermediate, it enables efficient introduction of fluorinated motifs under controlled conditions, supporting innovation in drug discovery and specialty chemical manufacturing.

Specifications

Molecular FormulaC₃H₃F₃O₄S
Molecular Weight192.11 g/mol
CAS Number680-15-9
AppearanceTransparent colorless to yellow liquid
Density1.509 g/mL at 25 °C (lit.)
Boiling Point117–118 °C (lit.)
Flash Point118 °F
Refractive Indexn²⁰/D 1.351 (lit.)

Industrial Applications

This fluorinated ester is primarily utilized as a synthetic intermediate in research and industrial settings. Its applications include:

  • Serving as a fluorinating agent or precursor in the synthesis of complex pharmaceutical active ingredients.
  • Enabling the construction of fluorine-rich scaffolds for structure-activity relationship (SAR) studies in medicinal chemistry.
  • Supporting the development of novel fluoropolymers and functional materials with enhanced thermal, chemical, or electronic properties.
  • Facilitating the preparation of other fluorosulfonyl-based reagents for selective transformations.

As part of a comprehensive fluorochemical portfolio, this product reflects our commitment to delivering high-integrity intermediates that meet stringent quality standards for global R&D and manufacturing operations.