Methyl 2,3-Difluoroisonicotinate
- CAS No.1353102-03-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity Methyl 2,3-Difluoroisonicotinate (CAS 1353102-03-0) designed for advanced pharmaceutical synthesis. Available in bulk quantities with comprehensive COA.
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Product Overview
Methyl 2,3-Difluoroisonicotinate is a highly specialized fluorinated pyridine derivative engineered for high-performance applications in modern pharmaceutical synthesis and organic chemistry. As a critical building block, this compound features a unique substitution pattern that significantly enhances metabolic stability and lipophilicity in downstream drug candidates. Our advanced manufacturing process ensures exceptional batch-to-batch consistency, making it an ideal choice for research and development teams focused on creating novel therapeutic agents and complex molecular structures.
The chemical structure incorporates two fluorine atoms strategically positioned at the 2 and 3 positions of the isonicotinate core. This specific arrangement offers distinct electronic properties that facilitate diverse coupling reactions and nucleophilic substitutions. Professionals in medicinal chemistry value this intermediate for its reliability in forming complex heterocyclic systems required for advanced organic synthesis. The stability of the pyridine ring under various reaction conditions further adds to its utility in multi-step synthesis pathways.
Key Specifications
| Parameter | Value |
|---|---|
| CAS Number | 1353102-03-0 |
| Molecular Formula | C7H5F2NO2 |
| Molecular Weight | 173.12 g/mol |
| Purity | ≥99.0% |
| Appearance | White to Off-White Powder |
| Boiling Point | 231.2±40.0 °C at 760 mmHg |
| Density | 1.3±0.1 g/cm3 |
| Flash Point | 93.6±27.3 °C |
| Refractive Index | 1.472 |
Industrial Applications
This fluorinated intermediate serves as a vital precursor in the production of various pharmaceutical active ingredients and agrochemical compounds. The introduction of fluorine into organic molecules is a strategic move to improve bioavailability, binding affinity, and resistance to metabolic degradation. Consequently, Methyl 2,3-Difluoroisonicotinate is frequently utilized in the development of kinase inhibitors, antiviral agents, and other targeted therapies requiring precise molecular architecture.
Our facility adheres to strict quality control protocols to guarantee that every batch meets the rigorous demands of the global pharmaceutical industry. The high purity level minimizes side reactions during synthesis, thereby improving overall yield and reducing purification costs for our clients. We support large-scale production needs with a robust supply chain capable of meeting international deadlines. Our technical team provides detailed guidance on optimal reaction conditions to maximize efficiency.
Quality Assurance And Storage
- Each shipment includes a detailed Certificate Of Analysis verifying purity, identity, and physical constants via HPLC and NMR.
- Products are packaged in secure 25kg drums with inner liners to prevent moisture contamination during international transit.
- Storage requires a cool, dry environment in tightly closed containers away from direct sunlight to maintain long-term stability.
- We offer comprehensive technical support for integration into your specific manufacturing process and scale-up activities.
- Custom synthesis options are available upon request for specialized research requirements and derivative exploration.
- Safety data sheets are provided to ensure compliant handling and workplace safety standards are maintained at all times.
Choosing the right chemical partner is essential for project success and regulatory compliance. We commit to delivering premium quality intermediates with transparent documentation and reliable logistics services worldwide. Contact our sales team today to discuss your bulk pricing requirements and obtain evaluation samples for your laboratory testing.
