Methyl 2,4-Difluorobenzoate
- CAS No.106614-28-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity Methyl 2,4-Difluorobenzoate (CAS 106614-28-2), a key fluorinated intermediate for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
Methyl 2,4-Difluorobenzoate is a high-value fluorinated aromatic ester widely employed as a building block in modern organic synthesis. With its dual ortho- and para-fluorine substitution pattern, this compound offers enhanced reactivity and selectivity in cross-coupling reactions, making it indispensable in the development of complex active pharmaceutical ingredients (APIs) and specialty agrochemicals.
Specifications
| Molecular Formula | C8H6F2O2 |
|---|---|
| Molecular Weight | 172.13 g/mol |
| Appearance | Colorless to pale yellow transparent liquid |
| Assay | ≥98.0% |
| Moisture | ≤0.5% |
| Density | 1.384 g/cm³ |
| Boiling Point | 128–129°C |
| Flash Point | 180°F (82.2°C) |
| Refractive Index | 1.4840 |
Industrial Applications
This fluorinated benzoate ester serves primarily as a versatile intermediate in multi-step synthetic pathways. Its applications include:
- Construction of fluorinated heterocyclic scaffolds in drug discovery programs
- Synthesis of kinase inhibitors and other targeted therapeutics
- Preparation of advanced agrochemical molecules requiring metabolic stability
- Use in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed transformations
Due to the electron-withdrawing nature of fluorine atoms, Methyl 2,4-Difluorobenzoate enhances electrophilicity at specific ring positions, enabling regioselective functionalization under mild conditions.
Handling and Storage
Store in a cool, dry, and well-ventilated area away from heat sources and incompatible materials. Keep container tightly closed when not in use. Standard industrial hygiene practices should be followed during handling.
