Methyl 2-aminothiazole-5-carboxylate
- CAS No.6633-61-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity Methyl 2-aminothiazole-5-carboxylate (CAS 6633-61-0) designed for pharmaceutical synthesis. Reliable supply with strict quality control.
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Product Overview
Methyl 2-aminothiazole-5-carboxylate is a sophisticated heterocyclic compound widely recognized for its critical role in modern medicinal chemistry. As a key thiazole derivative, this chemical building block features a robust aromatic structure that facilitates various coupling reactions essential for complex molecule assembly. Our facility specializes in the production of this high-value intermediate, ensuring consistent quality for downstream pharmaceutical applications.
The compound is characterized by its amino functional group and ester moiety, which provide versatile reactivity profiles for organic synthesis. It serves as a fundamental precursor in the development of kinase inhibitors and other targeted therapeutics. Manufacturers and research institutions rely on this material for its stability and predictable performance in multi-step synthesis routes.
Technical Specifications
| Parameter | Specification |
|---|---|
| Chemical Name | Methyl 2-aminothiazole-5-carboxylate |
| CAS Number | 6633-61-0 |
| Molecular Formula | C5H6N2O2S |
| Molecular Weight | 158.178 g/mol |
| Appearance | Brown or yellow powder |
| Assay (Purity) | ≥98.0% |
| Melting Point | 184-186°C |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 298.7±13.0 °C at 760 mmHg |
Industrial Applications
This intermediate is primarily utilized in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients (APIs). Notably, it acts as a crucial structural component in the manufacturing pathway of certain oncology therapeutics, including kinase inhibitors such as Dasatinib. The thiazole ring system provides necessary biological activity and metabolic stability to the final drug molecule.
Beyond oncology, this compound finds utility in the exploration of new chemical entities (NCEs) during drug discovery phases. Its compatibility with various catalytic systems allows chemists to construct diverse molecular libraries efficiently. Industrial users value this material for its high purity, which minimizes impurity carry-over in subsequent reaction steps.
Quality Assurance and Testing
Quality is paramount in our manufacturing process. Every batch of Methyl 2-aminothiazole-5-carboxylate undergoes rigorous analytical testing to confirm identity and purity. We employ advanced techniques including High-Performance Liquid Chromatography (HPLC), Nuclear Magnetic Resonance (NMR), and Mass Spectrometry (MS) to validate product specifications.
- Strict adherence to international quality management systems.
- Comprehensive Certificate of Analysis (COA) provided with each shipment.
- Traceability of raw materials and production batches.
- Regular stability testing to ensure shelf-life integrity.
Storage and Handling
To maintain optimal chemical stability, this product should be stored in a cool, ventilated environment away from direct sunlight and moisture. The material is packaged in secure 25 kg drums, though custom packaging solutions are available to meet specific logistical requirements. Proper handling procedures, including the use of personal protective equipment (PPE), are recommended during transfer and weighing operations to ensure safety.
