Methyl 2-Ethoxy-1H-Benzimidazole-4-Carboxylate
- CAS No.150058-27-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity Methyl 2-Ethoxy-1H-Benzimidazole-4-Carboxylate (CAS 150058-27-8) designed for pharmaceutical synthesis. Ideal intermediate for Candesartan production with strict quality control.
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Product Overview
Methyl 2-Ethoxy-1H-Benzimidazole-4-Carboxylate is a specialized pharmaceutical intermediate characterized by its high chemical stability and precise structural configuration. This benzimidazole derivative serves as a critical building block in the multi-step synthesis of advanced antihypertensive agents, specifically functioning as a key precursor in the manufacturing pathway of Candesartan. Our production facility adheres to rigorous quality management systems to ensure that every batch meets the stringent requirements demanded by modern API synthesis.
The compound features a unique ethoxy substitution pattern on the benzimidazole ring, which is essential for achieving the desired biological activity in the final drug product. As a trusted global manufacturer, we provide this intermediate with consistent lot-to-lot reproducibility, supporting pharmaceutical companies in maintaining their regulatory compliance and production efficiency.
Chemical Properties and Specifications
Quality control is paramount in the production of pharmaceutical intermediates. Our Methyl 2-Ethoxy-1H-Benzimidazole-4-Carboxylate undergoes comprehensive analytical testing using high-performance liquid chromatography (HPLC) and other advanced spectroscopic methods. The physical appearance is typically a maroon crystalline powder, indicative of its specific crystalline structure and purity profile.
| Parameter | Specification |
|---|---|
| CAS Number | 150058-27-8 |
| Molecular Formula | C11H12N2O3 |
| Molecular Weight | 220.23 g/mol |
| Appearance | Maroon crystalline powder |
| Assay (HPLC) | ≥99.0% |
| Max Individual Impurity | ≤0.5% |
| Total Impurities | ≤1.0% |
| Residue on Ignition | ≤0.5% |
| Loss on Drying | ≤1.0% |
| Density | 1.269 g/cm3 |
| Boiling Point | 373.1°C at 760 mmHg |
Industrial Applications
The primary application of this chemical is in the pharmaceutical industry, where it acts as a vital intermediate for the synthesis of Candesartan, a widely prescribed angiotensin II receptor blocker (ARB). The high purity level of our product ensures that downstream reactions proceed with optimal yield and minimal formation of by-products, which is crucial for cost-effective API manufacturing.
- Essential precursor for antihypertensive drug synthesis.
- Compatible with various organic synthesis routes requiring benzimidazole scaffolds.
- Supports scalable manufacturing processes for generic and branded medications.
- Utilized in research and development for novel cardiovascular therapeutics.
Storage and Handling
To maintain the integrity and stability of Methyl 2-Ethoxy-1H-Benzimidazole-4-Carboxylate, proper storage conditions are essential. The material should be kept in a cool, well-ventilated area away from direct sunlight and sources of ignition. Containers must be tightly sealed to prevent moisture absorption, which could affect the assay performance. We recommend standard industrial safety protocols during handling, including the use of appropriate personal protective equipment (PPE) to ensure operator safety.
Our packaging options are flexible, typically supplying 25 kg drums, but we can accommodate custom packaging requirements based on specific customer logistics and production needs. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) to verify compliance with stated specifications.
