Intermediates

Methyl 2-Oxoindoline-6-carboxylate

  • CAS No.14192-26-8
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity pharmaceutical intermediate used in the synthesis of Nintedanib, available in bulk quantities with comprehensive quality documentation.

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Product Technical Details

Product Overview

Methyl 2-Oxoindoline-6-carboxylate is a specialized organic compound widely recognized in the pharmaceutical industry for its critical role in the synthesis of advanced therapeutic agents. As a key building block, this chemical intermediate facilitates the construction of complex molecular structures required for modern medicine development. Our facility produces this compound under strict quality control protocols to ensure consistency and reliability for downstream manufacturing processes.

This substance is particularly valued for its stability and reactivity profile, making it an essential component in multi-step organic synthesis pathways. Researchers and production managers rely on high-grade intermediates like this to maintain the integrity of their final active pharmaceutical ingredients. We commit to delivering materials that meet rigorous international standards for pharmaceutical production.

Chemical Specifications

Understanding the physical and chemical properties of this intermediate is vital for process optimization. The compound exhibits specific characteristics that influence handling, storage, and reaction conditions. Our manufacturing process ensures that each batch conforms to the specified parameters required for successful integration into larger synthetic schemes.

ParameterValue
CAS Number14192-26-8
Molecular FormulaC10H9NO3
Molecular Weight191.18 g/mol
AppearanceOff-white powder
Purity≥98.0%
Melting Point184-190°C
Density1.283 g/cm3
Boiling Point388.1°C

Quality Assurance and Control

Quality is the cornerstone of our production philosophy. Every batch of Methyl 2-Oxoindoline-6-carboxylate undergoes comprehensive analytical testing before release. We utilize advanced chromatography and spectroscopy techniques to verify purity levels and identify potential impurities. This rigorous approach minimizes risks associated with variable raw materials in subsequent synthesis steps.

  • High-performance liquid chromatography (HPLC) for purity verification.
  • Nuclear magnetic resonance (NMR) for structural confirmation.
  • Strict monitoring of total impurities to ensure compliance with specifications.
  • Batch-specific Certificate of Analysis (COA) provided with every shipment.

Industrial Applications

The primary application of this chemical intermediate lies in the pharmaceutical sector, specifically serving as a precursor in the manufacturing of Nintedanib. This connection highlights its importance in the production of treatments for serious medical conditions. Beyond this specific use, the oxindole scaffold is versatile and finds utility in various medicinal chemistry research projects focused on kinase inhibitors and other therapeutic classes.

Our clients appreciate the reliability of our supply chain, which supports both research-scale requirements and large-scale commercial production. Whether for process development or full-scale manufacturing, our material provides a consistent foundation for chemical synthesis.

Packaging and Storage

Proper handling and storage are essential to maintain the quality of this intermediate during transit and warehousing. We offer flexible packaging solutions designed to protect the product from environmental factors such as moisture and light. Standard packaging includes durable drums suitable for international shipping, with custom options available upon request to meet specific logistical needs.

Storage recommendations include keeping the material in a cool, ventilated environment away from incompatible substances. Adhering to these guidelines ensures the longevity and stability of the product until it is ready for use in your manufacturing process. Our team is available to provide detailed safety data sheets and handling instructions to ensure compliance with local regulations.