N-Boc-(3S)-3-Phenyl-3-aminopropionaldehyde
- CAS No.135865-78-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity N-Boc-(3S)-3-phenyl-3-aminopropionaldehyde (CAS 135865-78-0), a key chiral intermediate for Maraviroc API synthesis. Ideal for pharmaceutical R&D and GMP-scale production.
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Product Overview
N-Boc-(3S)-3-Phenyl-3-aminopropionaldehyde is a high-value chiral building block widely employed in the synthesis of complex pharmaceutical active ingredients. This compound features a protected amine group via a tert-butoxycarbonyl (Boc) moiety and an aldehyde functionality adjacent to a phenyl-substituted stereocenter, making it particularly valuable for asymmetric synthesis and C–C bond-forming reactions in medicinal chemistry.
Specifications
| Molecular Formula | C₁₄H₁₉NO₃ |
|---|---|
| Molecular Weight | 249.31 g/mol |
| Density | 1.1 ± 0.1 g/cm³ |
| Boiling Point | 371.9 ± 35.0 °C at 760 mmHg |
| Flash Point | 178.7 ± 25.9 °C |
| Appearance | White foam |
| Assay (HPLC) | ≥98.0% |
| Heavy Metals | ≤10 ppm |
| Methanol Residue | ≤0.5% |
| Dichloromethane Residue | ≤0.5% |
| Loss on Drying | ≤0.5% |
| Residue on Ignition | ≤0.15% |
Industrial Applications
This enantiomerically pure intermediate plays a critical role in the multi-step synthesis of Maraviroc (CAS 376348-65-1), a clinically approved CCR5 antagonist used in HIV treatment regimens. Its structural features enable precise stereochemical control during downstream transformations, ensuring high yield and purity in final active pharmaceutical ingredient (API) manufacturing.
- Serves as a chiral synthon for antiviral drug development
- Compatible with standard peptide coupling and reductive amination protocols
- Stable under controlled storage conditions, facilitating global logistics
- Meets stringent quality requirements for use in GMP environments
Supplied in 25 kg drums or customized packaging upon request, this intermediate is stored in a cool, well-ventilated area to maintain integrity and performance throughout its shelf life.
