Intermediates

N-Boc-piperazine

  • CAS No.57260-71-6
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity N-Boc-piperazine (CAS 57260-71-6) serves as a essential building block for pharmaceutical synthesis. Available in bulk quantities with certified COA and global shipping.

Request Bulk Pricing

Product Technical Details

Product Overview

N-Boc-piperazine, chemically known as tert-butyl 1-piperazinecarboxylate, is a highly valued organic intermediate widely utilized in the pharmaceutical and fine chemical industries. This compound features a piperazine ring protected by a tert-butyloxycarbonyl (Boc) group, which provides exceptional stability during various synthetic transformations. As a key building block, it facilitates the construction of complex heterocyclic structures essential for modern drug discovery and development processes.

Our manufacturing facility adheres to strict quality control protocols to ensure every batch meets international standards. The production process involves advanced organic synthesis techniques designed to maximize yield while maintaining superior purity levels. This commitment to excellence makes our N-Boc-piperazine a preferred choice for research laboratories and large-scale production units alike.

Technical Specifications

The following table outlines the critical physical and chemical parameters verified through rigorous analytical testing. Each shipment is accompanied by a Certificate of Analysis (COA) to guarantee compliance with specified requirements.

Parameter Specification Typical Result
CAS Number 57260-71-6 57260-71-6
Molecular Formula C9H18N2O2 C9H18N2O2
Molecular Weight 186.25 g/mol 186.25 g/mol
Appearance White to light yellow powder Conform
Purity (HPLC) ≥98.0% 99.66%
Melting Point 47-49°C 48°C
Boiling Point 258°C at 760 mmHg Conform

Industrial Applications

This protected piperazine derivative plays a pivotal role in the synthesis of various pharmaceutical APIs and neurological therapeutics. The Boc protecting group allows for selective reactions on the secondary amine, enabling chemists to build complex molecular architectures with precision. Common applications include the production of antidepressants, antipsychotics, and other central nervous system agents where piperazine motifs are prevalent.

Beyond pharmaceuticals, N-Boc-piperazine is utilized in the development of agrochemicals and specialized polymers. Its versatility stems from the ease of deprotection under acidic conditions, which releases the free piperazine for subsequent coupling reactions. This flexibility makes it an indispensable reagent in multi-step synthesis routes requiring high fidelity and minimal side reactions.

Quality Assurance and Handling

We implement a comprehensive quality management system to monitor every stage of production. Raw materials are sourced from certified suppliers, and intermediate steps are checked using high-performance liquid chromatography (HPLC) and gas chromatography (GC). Final products undergo identity confirmation via infrared spectroscopy and nuclear magnetic resonance (NMR) to ensure structural integrity.

  • Consistent batch-to-batch reproducibility
  • Low impurity profile suitable for sensitive reactions
  • Full traceability from raw material to finished goods
  • Compliance with international safety and environmental regulations

Packaging and Storage

To maintain product stability during transit and storage, N-Boc-piperazine is packaged in secure 25kg cardboard drums or according to specific customer requirements. The packaging material is designed to prevent moisture ingress and protect against physical damage. For optimal preservation, the compound should be stored in a cool, dry, and well-closed container away from strong light and heat sources. Refrigeration is recommended for long-term storage to prevent degradation and maintain purity levels over extended periods.

Our logistics team ensures timely global delivery with proper documentation for customs clearance. Whether you require sample quantities for research or bulk volumes for commercial manufacturing, we are equipped to meet your supply chain needs with reliability and professionalism.