N-Fluorobenzenesulfonimide
- CAS No.133745-75-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity N-Fluorobenzenesulfonimide (NFSI), a versatile electrophilic fluorinating reagent widely used in pharmaceutical and agrochemical R&D.
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Product Overview
N-Fluorobenzenesulfonimide (NFSI) is a highly valued electrophilic fluorinating agent in modern organic synthesis. With the molecular formula C12H10FNO4S2 and a molecular weight of 315.34 g/mol, this compound serves as a stable, selective, and efficient source of positive fluorine ('F⁺') for introducing fluorine atoms into complex molecular architectures. Its robust chemical profile and ease of handling make it a preferred choice in both academic research and industrial-scale applications.
Specifications
| Molecular Formula | C12H10FNO4S2 |
|---|---|
| Molecular Weight | 315.34 g/mol |
| CAS Number | 133745-75-2 |
| Appearance | White crystal |
| Melting Point | 114–116 °C |
| Boiling Point | 244.5 °C at 760 mmHg |
| Density | 1.476 g/cm³ |
| Flash Point | 101.7 °C |
| Refractive Index | 1.424 |
Industrial Applications
NFSI is primarily employed as a key intermediate in the synthesis of fluorinated active pharmaceutical ingredients (APIs) and advanced agrochemicals. Its role extends to materials science, where it facilitates the development of novel fluorinated polymers and functional materials with enhanced thermal stability, lipophilicity, and metabolic resistance. As part of a comprehensive fluorochemical platform, this reagent supports innovation across pharmaceutical R&D, new material design, and next-generation crop protection solutions.
- Enables selective electrophilic fluorination under mild conditions
- Offers superior stability compared to other F⁺ reagents like Selectfluor or F-TEDA-BF4
- Compatible with a wide range of functional groups and reaction media
- Supports scalable and reproducible manufacturing processes
