N-Hydroxy-5-norbornene-2,3-dicarboximide
- CAS No.21715-90-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity N-Hydroxy-5-norbornene-2,3-dicarboximide (CAS 21715-90-2), a specialized condensation reagent for advanced organic synthesis.
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Product Overview
N-Hydroxy-5-norbornene-2,3-dicarboximide (HONB) is a high-value bicyclic imide derivative widely employed as a condensation reagent in complex organic synthesis. With its rigid norbornene scaffold and activated N–OH functionality, HONB facilitates efficient amide and ester bond formation under mild conditions, making it particularly valuable in the preparation of sensitive intermediates for pharmaceuticals and fine chemicals.
Specifications
| Molecular Formula | C9H9NO3 |
|---|---|
| Molecular Weight | 179.17 g/mol |
| CAS Number | 21715-90-2 |
| Appearance | Off-white to white crystalline powder |
| Purity (HPLC) | ≥99.0% |
| Melting Point | 165–170°C |
| Density | 1.574 g/cm³ |
| Boiling Point | 347.7°C |
| Refractive Index | 1.673 |
| HS Code | 2925190090 |
| UN Number | UN3077 |
| Hazard Class | Class 9 |
| Packing Group | III |
Industrial Applications
This compound serves primarily as a coupling agent in peptide synthesis and other carboxyl activation protocols. Its structural rigidity enhances selectivity and reduces racemization, which is critical in the production of chiral active pharmaceutical ingredients (APIs). Key advantages include:
- High reactivity with minimal side reactions
- Compatibility with standard solid-phase and solution-phase synthesis workflows
- Stability under ambient storage conditions when properly handled
Stored in a cool, well-ventilated area away from moisture and oxidizing agents, N-Hydroxy-5-norbornene-2,3-dicarboximide maintains integrity over extended periods. Standard packaging is 25 kg per drum, with custom options available for industrial-scale procurement.
