Intermediates

N-Hydroxysuccinimide

  • CAS No.6066-82-6
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity N-Hydroxysuccinimide (NHS) serves as a premier condensation reagent for organic synthesis and bioconjugation applications. Available in bulk quantities with comprehensive COA documentation.

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Product Technical Details

Product Overview

N-Hydroxysuccinimide, commonly abbreviated as NHS, is a highly versatile organic compound that plays a critical role in modern chemical synthesis and bioconjugation processes. As a fundamental building block in the pharmaceutical and biotechnology sectors, this reagent is primarily utilized to activate carboxylic acids, facilitating the formation of stable amide bonds. Our manufacturing process ensures that every batch meets stringent quality standards, making it an ideal choice for researchers and industrial producers alike who require reliability and consistency in their synthetic pathways.

The chemical stability and reactivity profile of N-Hydroxysuccinimide make it indispensable for creating active esters, which are key intermediates in peptide synthesis and protein modification. By converting carboxylic acids into NHS esters, chemists can achieve higher yields and cleaner reactions compared to traditional methods. This efficiency is crucial for scaling up production while maintaining the integrity of sensitive biological molecules.

Technical Specifications

We adhere to rigorous quality control protocols to guarantee the performance of our N-Hydroxysuccinimide. The following table outlines the key physical and chemical properties that define our premium grade product. Each parameter is verified through advanced analytical techniques to ensure compliance with international standards.

Parameter Specification
CAS Number 6066-82-6
Molecular Formula C4H5NO3
Molecular Weight 115.09 g/mol
Appearance White crystal powder
Purity (HPLC) ≥99.0%
Melting Point 95-98°C
Density 1.649 g/cm³

Our commitment to industrial purity means that impurities are minimized to prevent side reactions during downstream synthesis. This level of quality is essential for applications where even trace contaminants could affect the final product's efficacy or safety.

Industrial Applications

The utility of N-Hydroxysuccinimide extends across multiple domains within the chemical and life sciences industries. Its primary function as a condensation reagent allows for diverse applications that drive innovation in drug discovery and material science. Key uses include:

  • Peptide Synthesis: Facilitating the coupling of amino acids to form complex peptide chains with high fidelity.
  • Bioconjugation: Enabling the attachment of labels, drugs, or other functional groups to proteins and antibodies.
  • Polymer Modification: Acting as a cross-linking agent to alter the physical properties of polymeric materials.
  • Organic Synthesis: Serving as a reliable intermediate for creating various organic compounds through activated ester pathways.

These applications highlight the compound's flexibility and importance in developing advanced therapeutic solutions and functional materials. Whether used in academic research or large-scale manufacturing, NHS provides a robust foundation for chemical innovation.

Quality Assurance and Handling

To maintain the integrity of N-Hydroxysuccinimide during storage and transport, we recommend keeping the product in a cool, ventilated environment away from direct sunlight and moisture. Proper handling ensures that the reagent retains its reactivity and physical properties over time. We offer flexible packaging options, including standard 25 kg drums, which can be customized according to specific customer requirements to suit logistical needs.

Every shipment is accompanied by a Certificate of Analysis (COA), providing full transparency regarding the batch-specific test results. As a global manufacturer, we prioritize safety and compliance, ensuring that our supply chain meets all regulatory requirements. Partnering with us means accessing a reliable source of high-quality chemical intermediates backed by decades of industry expertise and customer support.