N-(tert-Butoxycarbonyl)glycylglycine
- CAS No.31972-52-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity N-(tert-Butoxycarbonyl)glycylglycine (Boc-Gly-Gly-OH), CAS 31972-52-8, is a key protected dipeptide intermediate widely used in peptide synthesis and pharmaceutical R&D.
Request Bulk PricingProduct Technical Details
Product Overview
N-(tert-Butoxycarbonyl)glycylglycine, commonly abbreviated as Boc-Gly-Gly-OH, is a protected dipeptide derivative featuring a tert-butoxycarbonyl (Boc) group on the N-terminus. With the CAS number 31972-52-8 and molecular formula C9H16N2O5, this compound serves as a critical building block in solid-phase and solution-phase peptide synthesis. Its high chemical stability and compatibility with standard coupling protocols make it indispensable in the development of complex peptide-based therapeutics and research reagents.
Specifications
| Molecular Formula | C9H16N2O5 |
|---|---|
| Molecular Weight | 232.23 g/mol |
| Appearance | White to off-white powder |
| Purity (HPLC) | ≥98% |
| Water Content (KF) | ≤0.5% |
| Density | 1.222 g/cm³ |
| Boiling Point | 488.1°C at 760 mmHg |
| Flash Point | 249°C |
| Refractive Index | 1.483 |
Industrial Applications
As a specialized amino acid derivative, N-(tert-Butoxycarbonyl)glycylglycine is primarily employed as a pharmaceutical intermediate in the synthesis of bioactive peptides, enzyme inhibitors, and drug candidates targeting metabolic and neurological pathways. Its Boc-protected structure ensures selective reactivity during multi-step syntheses, minimizing side reactions and improving overall yield. This intermediate is also valuable in academic and industrial laboratories for constructing peptide libraries and developing novel delivery systems.
- Essential for Fmoc/Boc orthogonal protection strategies in peptide chemistry
- Enables efficient elongation of glycine-rich peptide sequences
- Compatible with automated synthesizers and standard deprotection conditions
- Supports GMP-compliant manufacturing of clinical-stage peptide APIs
Storage & Handling
To maintain optimal stability and purity, store N-(tert-Butoxycarbonyl)glycylglycine at -15°C in a tightly sealed container. Keep in a cool, dry environment away from moisture and direct light. Packaging is typically provided in 25 kg drums, with custom options available upon request to meet specific logistical or regulatory requirements.
