N-tert-Butyl-6-chloro-4-(o-tolyl)nicotinamide
- CAS No.342417-04-3
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity N-tert-butyl-6-chloro-4-(o-tolyl)nicotinamide serves as a critical intermediate for Netupitant synthesis, ensuring reliable supply for pharmaceutical manufacturing.
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Product Overview
N-tert-Butyl-6-chloro-4-(o-tolyl)nicotinamide is a specialized organic compound engineered for high-performance pharmaceutical applications. As a key building block in the synthesis of advanced antiemetic agents, this intermediate meets rigorous quality standards required by global regulatory bodies. Our facility employs state-of-the-art synthetic methodologies to ensure consistent molecular integrity and exceptional purity levels suitable for large-scale API production.
Technical Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 342417-04-3 |
| Molecular Formula | C17H19ClN2O |
| Molecular Weight | 302.80 g/mol |
| Appearance | White to off-white powder |
| Assay (Purity) | ≥98.0% |
| Application | Netupitant Intermediate |
Industrial Applications
This compound functions primarily as a pivotal intermediate in the manufacturing pathway of Netupitant, a potent neurokinin-1 (NK1) receptor antagonist used in oncology support care. The structural precision of N-tert-butyl-6-chloro-4-(o-tolyl)nicotinamide is essential for achieving the desired pharmacological profile in the final active pharmaceutical ingredient. Pharmaceutical manufacturers rely on this material to maintain strict batch-to-batch consistency, minimizing downstream purification challenges and optimizing overall yield.
Quality Assurance and Advantages
- Superior Chemical Purity: Advanced crystallization techniques ensure assay levels exceeding 98.0 percent.
- Regulatory Compliance: Produced under strict quality management systems aligned with international pharmaceutical standards.
- Supply Chain Stability: Robust production capacity guarantees timely delivery for commercial-scale projects.
- Technical Support: Comprehensive documentation including Certificates of Analysis (COA) and method validation data available upon request.
Packaging and Storage
To preserve chemical stability, the product is packaged in durable 25 kg drums with inner liners designed to prevent moisture ingress and contamination. Custom packaging solutions are available to meet specific logistical requirements. Storage recommendations include maintaining the material in a cool, well-ventilated environment away from direct sunlight and incompatible substances. Proper handling protocols ensure the longevity and performance of the intermediate throughout its shelf life.
