N6-Trifluoroacetyl-L-Lysine
- CAS No.10009-20-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity N6-Trifluoroacetyl-L-Lysine (CAS 10009-20-8) designed for pharmaceutical synthesis, specifically as a key intermediate for ACE inhibitors like Lisinopril.
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Product Overview
N6-Trifluoroacetyl-L-Lysine, also known scientifically as Nε-Trifluoroacetyl-L-Lysine, is a highly specialized protected amino acid derivative essential in modern medicinal chemistry and peptide synthesis. This compound features a trifluoroacetyl protecting group on the epsilon-amino position of the lysine side chain, providing exceptional stability during complex synthetic routes. As a critical building block, it facilitates the precise construction of pharmaceutical active ingredients, ensuring high regioselectivity and minimizing side reactions during coupling processes.
Our manufacturing process adheres to strict international quality standards, delivering a product with consistent purity profiles suitable for large-scale API production. The trifluoroacetyl group offers distinct advantages over traditional protecting groups, including enhanced resistance to acidic conditions and improved solubility characteristics in various organic solvents. This makes it an indispensable reagent for chemists developing advanced therapeutic molecules, particularly within the cardiovascular and antihypertensive drug classes.
Key Specifications
| Parameter | Value |
|---|---|
| CAS Number | 10009-20-8 |
| Molecular Formula | C8H13F3N2O3 |
| Molecular Weight | 242.196 g/mol |
| Appearance | White to off-white powder |
| Assay (Purity) | ≥98.0% |
| Melting Point | 258°C |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 382.5±42.0 °C at 760 mmHg |
Industrial Applications
The primary application of N6-Trifluoroacetyl-L-Lysine lies in the synthesis of sophisticated pharmaceutical intermediates. It is notably utilized as a key precursor in the manufacturing of Lisinopril, a widely prescribed angiotensin-converting enzyme (ACE) inhibitor used to treat hypertension and heart failure. The structural integrity provided by the trifluoroacetyl moiety ensures that the lysine side chain remains inert during critical reaction steps, only to be deprotected under specific conditions to yield the final active pharmacophore.
Beyond ACE inhibitors, this protected amino acid finds utility in the development of peptide-based therapeutics and diagnostic agents. Researchers value its reliability in solid-phase peptide synthesis (SPPS) and solution-phase coupling reactions. The high optical purity of our L-isomer product guarantees that downstream biological activities are not compromised by racemic impurities, which is vital for regulatory compliance in drug submission dossiers.
Quality Assurance and Storage
We maintain a robust quality control framework to ensure every batch meets rigorous specifications. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, residual solvents, and heavy metal content. Our facility employs advanced analytical techniques, including HPLC and NMR, to verify chemical identity and potency.
- Packaging: Standard 25 kg drums, with customizable options available to suit specific logistical requirements.
- Storage Conditions: Store in a cool, ventilated place away from direct sunlight and moisture to maintain stability.
- Shelf Life: When stored under recommended conditions, the product retains its specified purity for extended periods.
- Safety: Handle with appropriate personal protective equipment (PPE) in accordance with standard laboratory safety protocols.
As a global manufacturer, we are committed to providing reliable supply chains for the pharmaceutical industry. Whether for pilot-scale research or commercial production, our N6-Trifluoroacetyl-L-Lysine delivers the performance and consistency required for high-stakes synthetic applications.
