Intermediates

o-Toluoyl chloride

  • CAS No.933-88-0
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity o-Toluoyl chloride (CAS 933-88-0) supplied as a colorless liquid for pharmaceutical synthesis. Ideal intermediate for producing advanced therapeutic agents.

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Product Technical Details

Product Overview

o-Toluoyl chloride represents a critical acylating agent within the realm of fine chemical synthesis and pharmaceutical manufacturing. Known chemically as 2-methylbenzoyl chloride, this compound serves as a versatile building block for constructing complex organic molecules. Our facility produces this reagent under strict quality control protocols to ensure consistent performance in downstream reactions. The material is characterized by its high reactivity towards nucleophiles, making it an essential component for introducing the o-toluoyl functional group into various molecular scaffolds.

As a leading global manufacturer, we understand the stringent requirements of modern pharmaceutical production. Therefore, our o-Toluoyl chloride is synthesized using advanced industrial processes that maximize yield while minimizing impurities. This commitment to quality ensures that chemists and process engineers can rely on our product for sensitive synthesis routes without compromising the integrity of the final active pharmaceutical ingredients.

Key Specifications

To guarantee transparency and reliability for our B2B partners, we provide comprehensive physical and chemical data for every batch. The following table outlines the standard specifications for our premium grade o-Toluoyl chloride. Please note that custom specifications may be available upon request for large-scale industrial projects.

ParameterSpecification
CAS Number933-88-0
Molecular FormulaC8H7ClO
Molecular Weight154.594 g/mol
AppearanceColorless to light yellow transparent liquid
Assay (Purity)≥99.0%
Density1.2±0.1 g/cm3
Boiling Point213.5±0.0 °C at 760 mmHg
Melting Point-18ºC
Flash Point84.1±11.9 °C

Industrial Applications

The primary utility of o-Toluoyl chloride lies in its role as a pharmaceutical intermediate. It is extensively utilized in the synthesis of various therapeutic compounds, including but not limited to intermediates for Tolvaptan. Beyond specific drug synthesis, this chemical reagent is valuable in the production of agrochemicals, dyes, and specialty polymers where acyl chloride functionality is required. Its ability to participate in Friedel-Crafts acylation and amide formation reactions makes it indispensable for organic synthesis laboratories and industrial plants alike.

For process development teams, our product offers a reliable benchmark for performance. Whether used in small-scale research or bulk manufacturing, the consistency of our supply chain ensures that production schedules are met without delay. We support our clients with technical data that facilitates safe and efficient integration into their existing manufacturing processes.

Quality Assurance and Packaging

Quality assurance is the cornerstone of our operation. Every drum of o-Toluoyl chloride is accompanied by a Certificate of Analysis (COA) that verifies compliance with the stated specifications. Our packaging is designed to maintain stability during transit and storage. The standard packing configuration is 25 kg per drum, though we offer flexible packaging solutions tailored to specific customer requirements and logistics needs.

Proper storage is essential to maintain the quality of this moisture-sensitive compound. We recommend storing the product in a cool, ventilated place away from direct sunlight and sources of ignition. Containers should remain tightly sealed when not in use to prevent hydrolysis. Our logistics team ensures that all safety regulations are followed during shipping, providing our global partners with peace of mind regarding regulatory compliance and product safety.