Intermediates

p-Bromofluorobenzene

  • CAS No.460-00-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity p-Bromofluorobenzene (CAS 460-00-4) designed for pharmaceutical and agrochemical synthesis. Reliable supply with strict quality control.

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Product Technical Details

Product Overview

p-Bromofluorobenzene serves as a fundamental fluorinated aromatic intermediate within the modern chemical industry. This compound is characterized by the presence of both bromine and fluorine substituents on a benzene ring, providing unique reactivity profiles essential for complex organic synthesis. Our facility produces this material under strict quality management systems to ensure consistency across batches. It is particularly valued for its stability and versatility in forming carbon-carbon and carbon-heteroatom bonds. The molecular structure allows for selective functionalization, making it a preferred choice for medicinal chemists and agrochemical developers. By leveraging advanced purification technologies, we deliver a product that meets rigorous international standards. This ensures downstream processes proceed without interference from impurities, ultimately saving time and resources in research and production scales.

Technical Specifications

ParameterValue
CAS Number460-00-4
Molecular FormulaC6H4BrF
Molecular Weight174.998 g/mol
AppearanceWhite to light yellow crystalline powder
Purity≥99.0%
Density1.593 g/mL at 25 °C
Boiling Point150 °C
Melting Point-16 °C
Flash Point140 °F
Refractive Index1.527

Industrial Applications

This fluorinated building block is extensively utilized in the synthesis of active pharmaceutical ingredients (APIs). The bromine atom facilitates palladium-catalyzed cross-coupling reactions, such as Suzuki or Heck couplings, while the fluorine atom often enhances the metabolic stability and bioavailability of the final drug molecule. Consequently, it is a key precursor in developing treatments for various therapeutic areas including oncology and central nervous system disorders. Beyond pharmaceuticals, p-Bromofluorobenzene finds significant application in agrochemical formulations. It serves as a starting material for herbicides and pesticides where fluorine incorporation improves environmental persistence and efficacy. Additionally, it is used in the production of liquid crystals and advanced polymeric materials where specific electronic properties are required for high-performance displays.

  • Pharmaceutical intermediate synthesis
  • Agrochemical active ingredient production
  • Organic light-emitting diode (OLED) materials
  • Custom organic synthesis projects
  • Fluorinated polymer manufacturing

Quality Assurance and Storage

We maintain a comprehensive quality control protocol that includes thorough testing via GC, HPLC, and NMR spectroscopy. Each shipment is accompanied by a Certificate of Analysis (COA) to verify compliance with specified parameters. Proper handling is essential to maintain product integrity. The material should be stored in a tightly closed container within a cool, dry, and well-ventilated area. Temperatures between 0 to 6 degrees Celsius are recommended for long-term stability. Always keep away from incompatible substances such as strong oxidizing agents. Packing options include 25kg drums, customizable based on client logistics requirements. Our global supply chain ensures timely delivery while maintaining safety standards during transit. For large-scale manufacturing needs, we offer competitive bulk pricing and dedicated technical support to optimize your synthesis routes. Contact our sales team for detailed safety data sheets and regulatory compliance documentation.