Intermediates

p-Toluenesulfonyl Isocyanate

  • CAS No.4083-64-1
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity p-Toluenesulfonyl Isocyanate (CAS 4083-64-1) designed for advanced organic synthesis applications. Available in bulk quantities with strict quality control.

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Product Technical Details

Product Overview

p-Toluenesulfonyl Isocyanate, frequently referred to as Tosyl Isocyanate, stands as a pivotal reagent in the realm of modern organic chemistry. This versatile sulfonylating agent is characterized by its high reactivity and specificity, making it an indispensable tool for chemists engaged in complex molecular constructions. Our facility produces this compound under rigorous quality standards to ensure consistent performance in downstream synthetic processes. As a leading global manufacturer, we understand the critical nature of supply chain reliability for industrial partners relying on precise chemical inputs for their research and production lines.

Key Physical and Chemical Properties

Understanding the physicochemical profile of this material is essential for safe handling and effective utilization. The substance presents as a colourless to yellow liquid, indicating high purity levels when properly stored. Its molecular structure, defined by the formula C8H7NO3S, contributes to its unique reactivity profile, particularly in nucleophilic addition reactions. The following table outlines the critical specifications that define our premium grade product:

PropertySpecification
CAS Number4083-64-1
Molecular FormulaC8H7NO3S
Molecular Weight197.211 g/mol
AppearanceColourless to yellow liquid
Assay (Purity)≥98.5%
Density1.3±0.1 g/cm3
Boiling Point288.8±9.0 °C at 760 mmHg
Melting Point5 °C
Flash Point128.5±18.7 °C

Industrial Applications and Reactivity

Primarily utilized as an organic synthesis intermediate, p-Toluenesulfonyl Isocyanate facilitates the formation of various functional groups including ureas, carbamates, and sulfonamides. Its role extends into the pharmaceutical and agrochemical sectors where it serves as a building block for active pharmaceutical ingredients (APIs) and crop protection agents. The reagent reacts efficiently with amines and alcohols, allowing for the streamlined development of complex molecular architectures. Researchers value this compound for its ability to introduce the tosyl group under mild conditions, thereby preserving sensitive functional groups elsewhere in the molecule. This capability makes it a preferred choice for multi-step synthesis routes requiring high fidelity and yield.

Quality Assurance and Packaging

We maintain a robust quality management system to guarantee that every batch meets the specified assay of greater than 98.5 percent. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) detailing batch-specific test results. Our packaging solutions are designed to maintain product integrity during transit, typically supplied in 200 kg drums. However, we offer flexible packaging options tailored to specific customer requirements to accommodate varying scales of operation from laboratory research to full-scale industrial production. Our logistics team ensures secure handling and timely delivery to destinations worldwide.

Storage and Safety Guidelines

To preserve the stability and efficacy of p-Toluenesulfonyl Isocyanate, proper storage conditions are imperative. The material should be stored in a cool, ventilated place away from direct sunlight and sources of ignition. It is crucial to keep containers tightly sealed to prevent moisture ingress, as the compound may react with water. Personnel handling this chemical should adhere to standard safety protocols, including the use of appropriate personal protective equipment. By following these guidelines, users can ensure a safe working environment while maximizing the utility of this high-performance chemical intermediate.