Poly(ethylene glycol) diglycidyl ether
- CAS No.39443-66-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity Poly(ethylene glycol) diglycidyl ether (CAS 39443-66-8), a key epoxy-functionalized intermediate for pharmaceutical synthesis.
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Product Overview
Poly(ethylene glycol) diglycidyl ether (CAS 39443-66-8) is a high-purity, bifunctional epoxy compound widely employed as a critical chemical intermediate in the pharmaceutical and fine chemical industries. Featuring two reactive glycidyl ether groups at both ends of a poly(ethylene glycol) backbone, this molecule serves as a versatile building block for synthesizing complex active pharmaceutical ingredients (APIs), including tricyclic antidepressants such as Doxepin Hydrochloride.
Specifications
| Molecular Formula | (C₃H₅ClO·(C₂H₄O)ₙH₂O)ₓ |
|---|---|
| Molecular Weight | 218.25 g/mol |
| Density | 1.14 g/mL at 25°C |
| Boiling Point | 402.1°C at 760 mmHg |
| Flash Point | 387°F (197°C) |
| Refractive Index | n²⁰/D = 1.47 |
| Storage Condition | –20°C, in a tightly sealed container under dry, well-ventilated conditions |
Quality Control Parameters
| Appearance | Colorless to light yellow transparent liquid |
|---|---|
| Assay | ≥99.0% |
| Color (APHA) | ≤60 |
| Epoxy Value | 0.32–0.35 Eq/100g |
| Epoxide Equivalent Weight | 270–313 g/eq |
| Organic Chlorine | ≤0.02 Eq/100g |
| Inorganic Chlorine | ≤0.005 Eq/100g |
| Water Content | ≤0.1% |
| Viscosity (25°C) | ≤120 mPa·s |
Industrial Applications
This compound is primarily utilized as a specialty intermediate in advanced organic synthesis, particularly in the production of neurological therapeutics. Its dual epoxy functionality enables crosslinking, chain extension, and functionalization reactions under controlled conditions, making it indispensable in multi-step API manufacturing processes. Due to its high reactivity and purity profile, it is also suitable for research-scale development of novel drug candidates requiring precise molecular architecture.
As a non-formulation-ready raw material, Poly(ethylene glycol) diglycidyl ether is classified as a synthetic intermediate rather than a direct-use active ingredient, aligning with strict regulatory frameworks for B2B chemical supply.
