(R)-(+)-1-Boc-3-aminopyrrolidine
- CAS No.147081-49-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity (R)-(+)-1-Boc-3-aminopyrrolidine (CAS 147081-49-0) designed for pharmaceutical synthesis. Ideal chiral intermediate for Linagliptin production with ≥98.0% purity.
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Product Overview
(R)-(+)-1-Boc-3-aminopyrrolidine represents a critical chiral building block within the realm of advanced organic synthesis and pharmaceutical manufacturing. As a protected amine derivative, this compound features a pyrrolidine ring structure stabilized by a tert-butyloxycarbonyl (Boc) group, ensuring high chemical stability during complex multi-step reactions. Our facility specializes in the production of this high-value intermediate, adhering to strict quality control protocols to guarantee consistency and reliability for downstream applications.
The stereochemistry of this molecule is paramount, specifically the (R)-enantiomeric configuration, which is essential for the biological activity of target pharmaceutical agents. We employ rigorous chiral separation and synthesis technologies to maintain exceptional enantiomeric excess. This level of precision is vital for clients developing novel therapeutic solutions where molecular geometry dictates efficacy and safety profiles.
Technical Specifications
| Parameter | Value |
|---|---|
| CAS Number | 147081-49-0 |
| Molecular Formula | C9H18N2O2 |
| Molecular Weight | 186.25 g/mol |
| Appearance | Light yellow liquid |
| Purity | ≥98.0% |
| Density | 1.098 g/cm³ |
| Boiling Point | 243.244°C |
| Flash Point | 91°C |
| Refractive Index | 1.4720 |
Industrial Applications
This compound serves primarily as a key intermediate in the synthesis of Linagliptin, a prominent dipeptidyl peptidase-4 (DPP-4) inhibitor used in the management of type 2 diabetes. The structural integrity provided by the Boc protection group allows for selective functionalization during the drug manufacturing process. Beyond this specific application, the molecule is versatile enough for use in various medicinal chemistry campaigns requiring chiral pyrrolidine scaffolds.
Our production capabilities support large-scale industrial demands while maintaining the flexibility to accommodate custom research requirements. We understand the complexities of supply chain management in the pharmaceutical sector and offer scalable solutions that align with your project timelines. Whether for clinical trial material or commercial production, our manufacturing processes are designed to meet evolving industry standards.
Quality Assurance and Compliance
Quality is the cornerstone of our operation. Each batch of (R)-(+)-1-Boc-3-aminopyrrolidine undergoes comprehensive analytical testing, including HPLC, NMR, and moisture analysis, to verify compliance with specified parameters. We provide a Certificate of Analysis (COA) with every shipment, ensuring full transparency and traceability. Our facilities operate under guidelines that emphasize safety, environmental responsibility, and product integrity.
Regarding intellectual property, we strictly adhere to international patent regulations. Products covered by valid patents will not be offered to countries where such patents are in force. We recommend clients conduct their own freedom-to-operate assessments before procurement. Storage recommendations include keeping the material in a cool, ventilated area away from incompatible substances to preserve stability. Packaging options include 200 kg drums or customized solutions based on specific logistical needs.
