(R)-(+)-2-Tetrahydrofuroic Acid
- CAS No.87392-05-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity chiral building block for asymmetric synthesis. Verified optical rotation and assay ≥99.0% for reliable pharmaceutical manufacturing.
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Product Overview
(R)-(+)-2-Tetrahydrofuroic Acid represents a critical chiral intermediate in the field of fine chemical synthesis and pharmaceutical development. As a versatile carboxylic acid derivative featuring a tetrahydrofuran ring, this compound serves as an essential building block for constructing complex molecular architectures. The specific stereochemistry at the 2-position ensures high enantioselectivity in downstream reactions, making it indispensable for the production of active pharmaceutical ingredients (APIs) and advanced organic materials.
Our manufacturing process emphasizes strict control over optical purity and chemical stability. The product is supplied as a transparent to pale yellow viscous liquid, ready for immediate use in various synthetic pathways. We understand the rigorous demands of modern medicinal chemistry, which is why our production facilities adhere to comprehensive quality management systems to guarantee batch-to-batch consistency.
Key Specifications
The following table outlines the critical quality attributes verified through our internal analytical laboratories. Each batch undergoes thorough testing to ensure compliance with enterprise standards and client-specific requirements.
| Items of Analysis | Standard of Analysis | Test Results |
|---|---|---|
| Appearance | Colorless to light yellow viscous liquid | Light yellow Viscous liquid |
| Specific Rotation | ≥ +21° (Chloroform 20 °C) | +24° |
| Water Content | ≤ 0.5% | 0.034% |
| Optical Purity | ≥ 95.0% e.e | 96.2% e.e |
| Assay (GC/HPLC) | ≥ 99.0% | 99.5% |
| Conclusion | Conforms to Factory Standard | |
Industrial Applications
This chiral acid is primarily utilized in the synthesis of pharmaceutical intermediates where stereochemical integrity is paramount. It acts as a key precursor in the development of neurological therapeutics and cardiovascular medications. The tetrahydrofuran moiety provides a rigid structural framework that enhances the binding affinity of final drug candidates. Additionally, it is employed in the preparation of specialized ligands for asymmetric catalysis, enabling chemists to achieve high enantiomeric excess in complex transformations.
Beyond pharmaceuticals, this compound finds utility in the creation of agrochemicals and fine fragrances where specific olfactory profiles or biological activities are required. Its reactivity allows for diverse functionalization, including amidation, esterification, and reduction, offering synthetic flexibility to process chemists.
Quality Assurance and Storage
We maintain a robust quality control protocol that includes raw material screening, in-process monitoring, and final product verification. Every shipment is accompanied by a Certificate of Analysis (COA) detailing the specific test results for that batch. To maintain optimal stability, we recommend storing the product in a cool, dry place away from direct sunlight and moisture. Proper sealing is essential to prevent hydration or oxidation during long-term storage.
- Strict adherence to ISO-based quality management systems.
- Advanced chromatographic methods for purity verification.
- Secure packaging to ensure safety during global transit.
- Dedicated technical support for synthesis route optimization.
