(R)-3-Aminobutan-1-ol
- CAS No.61477-40-5
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity (R)-3-Aminobutan-1-ol (CAS 61477-40-5) is a key chiral intermediate used in the synthesis of advanced antiviral pharmaceuticals such as Dolutegravir.
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Product Overview
(R)-3-Aminobutan-1-ol is a high-value chiral aliphatic amino alcohol widely employed as a critical synthetic intermediate in the pharmaceutical industry. With its well-defined stereochemistry and excellent reactivity profile, this compound serves as a foundational building block for complex active pharmaceutical ingredients (APIs), particularly in the development of integrase inhibitors like Dolutegravir.
Specifications
| Molecular Formula | C₄H₁₁NO |
|---|---|
| Molecular Weight | 89.136 g/mol |
| Density | 0.9 ± 0.1 g/cm³ |
| Boiling Point | 168.3 ± 13.0 °C at 760 mmHg |
| Flash Point | 55.6 ± 19.8 °C |
| Vapour Pressure | 0.5 ± 0.7 mmHg at 25 °C |
| Refractive Index | 1.446 |
Quality Control & Purity Profile
Our (R)-3-Aminobutan-1-ol is manufactured under stringent quality control protocols to ensure exceptional enantiomeric and chemical purity, meeting the demanding standards of modern pharmaceutical synthesis:
- Assay (GC): ≥99.0%
- Any individual impurity: ≤0.25%
- Total impurities: ≤1.0%
- Enantiomeric impurity (S-isomer): ≤0.1%
- Moisture content: ≤1.0%
Industrial Applications
This chiral intermediate is primarily utilized in the multi-step synthesis of Dolutegravir (CAS 1051375-16-6), a potent HIV integrase strand transfer inhibitor. Its defined (R)-configuration is essential for achieving the correct stereochemistry in the final API, directly impacting therapeutic efficacy and safety. Beyond antiviral applications, it may also serve as a versatile synthon in the preparation of other bioactive molecules requiring a β-amino alcohol motif with precise chirality.
Handling & Storage
Supplied as a colorless clear liquid, (R)-3-Aminobutan-1-ol should be stored in a cool, dry, and well-ventilated area away from heat sources and incompatible materials. Standard packaging is 200 kg per drum, with custom packaging available upon request to meet specific logistical or regulatory requirements.
