(R)-5-Hydroxymethyl Tolterodine
- CAS No.207679-81-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity (R)-5-Hydroxymethyl Tolterodine, a key chiral intermediate for the synthesis of Fesoterodine Fumarate, manufactured under strict GMP-compliant conditions.
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Product Overview
(R)-5-Hydroxymethyl Tolterodine (CAS 207679-81-0) is a high-value chiral pharmaceutical intermediate used primarily in the synthesis of Fesoterodine Fumarate, a clinically approved antimuscarinic agent for overactive bladder treatment. This enantiomerically pure compound features a well-defined stereochemistry critical to the pharmacological activity of the final active pharmaceutical ingredient (API). Our product is synthesized and purified using advanced organic chemistry methodologies to ensure exceptional enantiomeric excess and batch-to-batch consistency.
Specifications
| Molecular Formula | C22H31NO2 |
|---|---|
| Molecular Weight | 341.49 g/mol |
| Appearance | Pale yellow solid |
| Assay (HPLC) | ≥98.0% |
| Melting Point | 68–72 °C |
| Density | 1.1 ± 0.1 g/cm³ |
| Boiling Point | 490.7 ± 45.0 °C at 760 mmHg |
| Flash Point | 233.2 ± 27.4 °C |
Industrial Applications
This compound serves exclusively as a synthetic building block in regulated pharmaceutical manufacturing environments. Key applications include:
- Chiral precursor in the multi-step synthesis of Fesoterodine Fumarate (CAS 286930-03-8)
- Reference standard for analytical method development and validation
- Intermediate for structure-activity relationship (SAR) studies in muscarinic receptor antagonists
Due to its role in API synthesis, stringent quality control protocols—including full spectral characterization (NMR, MS, HPLC), residual solvent analysis, and heavy metal testing—are applied to every batch. The product is not intended for direct human or veterinary use.
Handling and Storage
Store in a cool, dry, and well-ventilated area away from direct sunlight and incompatible materials. Keep container tightly sealed under inert atmosphere when not in use to prevent moisture absorption or oxidative degradation. Standard industrial hygiene practices should be followed during handling.
