Intermediates

(S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid

  • CAS No.85977-52-2
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity (S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid (CAS 85977-52-2) designed for pharmaceutical synthesis. Reliable supply for Palonosetron intermediates with strict quality control.

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Product Technical Details

Product Overview

Welcome to our detailed specification page for (S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid, a critical chiral building block in modern medicinal chemistry. This high-value intermediate is specifically engineered for use in the synthesis of complex pharmaceutical compounds, including antiemetic agents. Our facility adheres to rigorous international standards to ensure that every batch meets the highest levels of chemical purity and stereochemical integrity. As a trusted global manufacturer, we provide consistent supply chains for research and industrial production needs.

The molecular structure features a tetrahydronaphthalene scaffold with a defined chiral center at the 1-position, making it indispensable for asymmetric synthesis routes. The S-enantiomer configuration is crucial for the biological activity of downstream pharmaceutical products. Our advanced production capabilities allow us to maintain tight control over enantiomeric excess, ensuring optimal performance in your specific application protocols.

Technical Specifications

We maintain strict quality control measures throughout the manufacturing process. The following table outlines the key physical and chemical properties verified by our quality assurance team. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) to guarantee compliance with specified parameters.

ParameterSpecification
CAS Number85977-52-2
Molecular FormulaC11H12O2
Molecular Weight176.21 g/mol
AppearanceCrystalline white or yellow powder
Purity (HPLC)≥99.0%
Loss on Drying≤0.1%
Heavy Metals≤10 ppm
Inorganic Salt≤0.1%
Melting Point54-56 °C

Industrial Applications

This chiral acid serves as a vital precursor in the pharmaceutical industry, particularly in the production of specialized therapeutic intermediates. It is prominently used in the synthesis pathway of Palonosetron hydrochloride, a potent serotonin 5-HT3 receptor antagonist. The high stereochemical purity of our product ensures efficient downstream reactions, minimizing waste and maximizing yield in multi-step synthesis processes.

Beyond specific drug synthesis, this compound is utilized in various organic synthesis applications requiring a rigid bicyclic structure with a carboxylic acid functional group. Researchers value this material for its stability and reactivity profile, which facilitates diverse chemical transformations. Our team supports clients with technical data to optimize integration into their specific formulation or synthesis workflows.

Quality Assurance and Storage

Quality is the cornerstone of our operation. Every batch undergoes extensive testing using advanced analytical techniques such as HPLC, NMR, and Mass Spectrometry. We ensure that impurities are kept to minimal levels to prevent interference with sensitive catalytic processes. Our packaging solutions are designed to protect the product from environmental factors during transit.

  • Packaged in 25kg cardboard drums or customized containers.
  • Stored in a cool, dry, and well-closed container.
  • Protected from moisture, strong light, and heat sources.
  • Shelf life maintained under recommended storage conditions.

We offer global shipping services with full documentation support. Our commitment to safety and compliance ensures that all materials are handled according to international chemical safety regulations. For bulk orders or custom synthesis requirements, our technical sales team is available to discuss specific needs and provide competitive pricing structures tailored to your production volume.