(S)-(+)-1,2-Propanediol
- CAS No.4254-15-3
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity (S)-(+)-1,2-Propanediol (CAS 4254-15-3), a chiral building block for asymmetric synthesis and pharmaceutical intermediates.
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Product Overview
(S)-(+)-1,2-Propanediol is a high-value chiral diol widely employed as a key intermediate in the synthesis of enantiomerically pure pharmaceuticals, agrochemicals, and fine chemicals. With a molecular formula of C3H8O2 and a molecular weight of 76.09 g/mol, this optically active compound serves as a versatile synthon in asymmetric organic transformations due to its well-defined stereochemistry and bifunctional hydroxyl groups.
Specifications
| Purity | ≥99.5% (Typical: 99.9%) |
|---|---|
| Molecular Formula | C3H8O2 |
| Molecular Weight | 76.09 g/mol |
| Appearance | Colorless transparent liquid |
| Melting Point | -59°C |
| Boiling Point | 186–188°C at 765 mmHg |
| Density | 1.036 g/cm³ |
| Refractive Index | 1.431–1.435 |
| Moisture | ≤0.3% (Typical: 0.12%) |
| R-(-)-1,2-Propanediol (Enantiomeric Impurity) | ≤1.0% (Typical: 0.4%) |
| Total Impurities | ≤0.5% (Typical: 0.1%) |
| Peroxide Content | ≤3 ppm |
Industrial Applications
As a chiral auxiliary and precursor, (S)-(+)-1,2-Propanediol is extensively used in the production of enantioselective active pharmaceutical ingredients (APIs), particularly in cardiovascular, antiviral, and anti-inflammatory drug pathways. It also functions as a building block for chiral ligands, catalysts, and specialty polymers requiring defined stereochemistry. Additionally, it finds niche applications in the formulation of high-performance liquid chromatography (HPLC) mobile phases for chiral separations.
- Serves as a critical starting material in asymmetric synthesis
- Enables production of single-enantiomer therapeutics
- Compatible with green chemistry protocols due to low toxicity profile
- Stable under standard storage conditions when protected from light and moisture
For optimal stability, store in a tightly sealed container in a cool, dry, and well-ventilated area away from direct sunlight. Certificate of Analysis (COA) and regulatory documentation are available upon request for qualified B2B customers.
